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Paul E. Monahan

Researcher at University of North Carolina at Chapel Hill

Publications -  95
Citations -  5431

Paul E. Monahan is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Factor IX & Adeno-associated virus. The author has an hindex of 36, co-authored 90 publications receiving 4916 citations. Previous affiliations of Paul E. Monahan include Shire plc & Takeda Pharmaceutical Company.

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Self-complementary recombinant adeno-associated virus (scAAV) vectors promote efficient transduction independently of DNA synthesis.

D M McCarty, +2 more
- 01 Aug 2001 - 
TL;DR: This work generated and characterized scAAV vectors, which represent a biochemical intermediate in rAAV transduction and should provide new insights into the biology of vector transduction.
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Adeno-associated virus terminal repeat (TR) mutant generates self-complementary vectors to overcome the rate-limiting step to transduction in vivo.

D M McCarty, +6 more
- 01 Dec 2003 - 
TL;DR: This study confirms earlier predictions that complementary-strand DNA synthesis is the primary barrier to rAAV-2 transduction, and provides an extremely efficient vector for gene transfer into many types of cells in vivo.
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Phase 1 Gene Therapy for Duchenne Muscular Dystrophy Using a Translational Optimized AAV Vector

Dawn E. Bowles, +14 more
- 01 Feb 2012 - 
TL;DR: This trial established that rationally designed AAV2.5 vector was safe and well tolerated, lays the foundation of customizing AAV vectors that best suit the clinical objective and should usher in the next generation of viral delivery systems for human gene transfer.
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AAV vectors : is clinical success on the horizon?

Paul E. Monahan, +1 more
- 01 Jan 2000 - 
TL;DR: Production improvements will be complemented in the coming years with understanding of and innovations in the targeting and packaging of rAAV, the design of transgene cassettes, and the host immune response to the vectors.
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Adeno-associated virus vectors for gene therapy: more pros than cons?

Paul E. Monahan, +1 more
- 01 Nov 2000 - 
TL;DR: This review examines a number of long-standing concerns regarding the utility of AAV for gene transfer in light of many new insights into the biology, immunology and production of A AV.