P
Paul E. Szmitko
Researcher at University of Toronto
Publications - 44
Citations - 5341
Paul E. Szmitko is an academic researcher from University of Toronto. The author has contributed to research in topics: Endothelial stem cell & Endothelium. The author has an hindex of 26, co-authored 44 publications receiving 5132 citations. Previous affiliations of Paul E. Szmitko include Sunnybrook Health Sciences Centre & Toronto General Hospital.
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Journal ArticleDOI
Adipokines: molecular links between obesity and atheroslcerosis.
TL;DR: The role of adipose tissue in the development of obesity-linked insulin resistance, metabolic syndrome, and diabetes will be reviewed, including an examination of the molecular links between obesity and atherosclerosis, namely, the effects of fat-derived adipokines.
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A population-based study of the drug interaction between proton pump inhibitors and clopidogrel
David N. Juurlink,Tara Gomes,Dennis T. Ko,Dennis T. Ko,Paul E. Szmitko,Peter C. Austin,Jack V. Tu,Jack V. Tu,David Henry,Alex Kopp,Muhammad Mamdani +10 more
TL;DR: Among patients receiving clopidogrel following acute myocardial infarction, concomitant therapy with proton pump inhibitors other than pantoprazole was associated with a loss of the beneficial effects of clopIDogrel and an increased risk of reinfarction.
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C-Reactive Protein Attenuates Endothelial Progenitor Cell Survival, Differentiation, and Function Further Evidence of a Mechanistic Link Between C-Reactive Protein and Cardiovascular Disease
Subodh Verma,Michael A. Kuliszewski,Shu Hong Li,Paul E. Szmitko,Liana Zucco,Chao-Hung Wang,Mitesh V. Badiwala,Donald A.G. Mickle,Richard D. Weisel,Paul W.M. Fedak,Duncan J. Stewart,Michael Kutryk +11 more
TL;DR: Human recombinant CRP, at concentrations known to predict adverse vascular outcomes, directly inhibits EPC differentiation, survival, and function, key components of angiogenesis and the response to chronic ischemia.
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C-Reactive Protein Upregulates Angiotensin Type 1 Receptors in Vascular Smooth Muscle
Chao-Hung Wang,Shu-Hong Li,Richard D. Weisel,Paul W.M. Fedak,Aaron S. Dumont,Paul E. Szmitko,Ren-Ke Li,Donald A.G. Mickle,Subodh Verma +8 more
TL;DR: CRP, at concentrations known to predict cardiovascular events, upregulates AT1-R–mediated atherosclerotic events in vascular smooth muscle in vitro and in vivo, lending credence to the notion that CRP functions as a proatherosclerosis factor as well as a powerful risk marker.
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Endothelial Progenitor Cells New Hope for a Broken Heart
Paul E. Szmitko,Paul W.M. Fedak,Richard D. Weisel,Duncan J. Stewart,Michael J.B. Kutryk,Subodh Verma +5 more
TL;DR: This From Bench to Bedside article will explore the current concept of an EPC, the role EPCs play in neovascularization, the strategies used to maximize EPC number and function, the experimental and clinical evidence supporting EPC utility, and the future direction of EPC research.