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Paul F. Fitzpatrick
Researcher at University of Texas Health Science Center at San Antonio
Publications - 195
Citations - 7045
Paul F. Fitzpatrick is an academic researcher from University of Texas Health Science Center at San Antonio. The author has contributed to research in topics: Tyrosine hydroxylase & Phenylalanine hydroxylase. The author has an hindex of 42, co-authored 192 publications receiving 6514 citations. Previous affiliations of Paul F. Fitzpatrick include Brookhaven National Laboratory & Texas A&M University.
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Journal ArticleDOI
Tetrahydropterin-dependent amino acid hydroxylases.
TL;DR: Reversible phosphorylation of serine residues in the regulatory domains affects the activities of all three enzymes, and phenylalanine hydroxylase is allosterically regulated by its substrates, phenylAlanine and tetrahydrobiopterin.
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Crystal structure of tyrosine hydroxylase at 2.3 A and its implications for inherited neurodegenerative diseases.
Kenneth E. Goodwill,Christelle Sabatier,Cara B. Marks,Cara B. Marks,Reetta Raag,Paul F. Fitzpatrick,Raymond C. Stevens +6 more
TL;DR: The structure provides a rationale for the effect of point mutations in TyrOH that cause L-DOPA responsive parkinsonism and Segawa's syndrome.
Journal ArticleDOI
Oxidation of amines by flavoproteins
TL;DR: This review discusses the present understanding of the mechanisms of amine and amino acid oxidation by flavoproteins, focusing on two structural families, the D-amino acid oxidase/sarcosine oxidase family and the monoamine oxidasefamily.
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Structures and mechanism of the monoamine oxidase family
TL;DR: The present review compares the structures of different members of the monoamine oxidase family of flavoproteins and the various mechanistic proposals.