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Paul S. Masters
Researcher at New York State Department of Health
Publications - 56
Citations - 5777
Paul S. Masters is an academic researcher from New York State Department of Health. The author has contributed to research in topics: Coronavirus & Mouse hepatitis virus. The author has an hindex of 35, co-authored 56 publications receiving 5045 citations. Previous affiliations of Paul S. Masters include University at Albany, SUNY & Wadsworth Center.
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Book ChapterDOI
The molecular biology of coronaviruses.
TL;DR: This review summarizes both classical and contemporary discoveries in the study of the molecular biology of these infectious agents, with particular emphasis on the nature and recognition of viral receptors, viral RNA synthesis, and the molecular interactions governing virion assembly.
Journal ArticleDOI
Retargeting of Coronavirus by Substitution of the Spike Glycoprotein Ectodomain: Crossing the Host Cell Species Barrier
TL;DR: FMHV is potentially the ideal recipient virus for carrying out reverse genetics of MHV by targeted RNA recombination, since it presents the possibility of selecting recombinants that have regained the ability to replicate in murine cells.
Journal ArticleDOI
Coronavirus particle assembly: primary structure requirements of the membrane protein.
TL;DR: The results supported a critical role for this domain of M in viral assembly, although the M carboxy terminus was more tolerant of alteration in the complete virion than in virus-like particles, likely because of the stabilization of virions by additional intermolecular interactions.
Journal ArticleDOI
The group-specific murine coronavirus genes are not essential, but their deletion, by reverse genetics, is attenuating in the natural host.
TL;DR: It is concluded that the MHV group-specific genes are nonessential, accessory genes, which seems to provide an attractive approach to generate attenuated live coronavirus vaccines.
Journal ArticleDOI
Analysis of constructed E gene mutants of mouse hepatitis virus confirms a pivotal role for E protein in coronavirus assembly.
TL;DR: An important, probably essential, role for the E protein in coronavirus morphogenesis is demonstrated, as clustered charged-to-alanine mutagenesis on the E gene was carried out and the resulting mutations into the MHV genome by targeted recombination.