P
Paul W. O' Toole
Researcher at University College Cork
Publications - 10
Citations - 683
Paul W. O' Toole is an academic researcher from University College Cork. The author has contributed to research in topics: Gut flora & Genome. The author has an hindex of 7, co-authored 10 publications receiving 531 citations.
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Journal ArticleDOI
Evolution of gut microbiota composition from birth to 24 weeks in the INFANTMET Cohort.
Cian J. Hill,Denise B. Lynch,Kiera Murphy,Kiera Murphy,Marynka Ulaszewska,Ian B. Jeffery,Carol Anne O'Shea,Claire Watkins,Eugene M. Dempsey,Fulvio Mattivi,Kieran Tuohy,R. Paul Ross,C. Anthony Ryan,Paul W. O' Toole,Catherine Stanton,Catherine Stanton +15 more
TL;DR: These findings confirm that mode of delivery and gestational age both have significant effects on early neonatal microbiota composition and there is also a significant difference between the metabolite profile of FT and PT infants.
Journal ArticleDOI
The core faecal bacterial microbiome of Irish Thoroughbred racehorses
Michelle M O’ Donnell,Michelle M O’ Donnell,Hugh M. B. Harris,Ian B. Jeffery,Marcus J. Claesson,B. Younge,Paul W. O' Toole,R.P. Ross +7 more
TL;DR: The gut microbiota in six healthy Irish thoroughbred racehorses was characterized and showed it to be dominated by the phyla Firmicutes, Bacteroidetes, Proteobacteria, Verrucomicrobia, Actinob bacteria, Euryarchaeota, Fibrobacteres and Spirochaetes.
Journal ArticleDOI
Genome sequences and comparative genomics of two Lactobacillus ruminis strains from the bovine and human intestinal tracts.
Brian M. Forde,B. Anne Neville,Michelle M O’ Donnell,Michelle M O’ Donnell,Eliette Riboulet-Bisson,Marcus J. Claesson,Avril Coghlan,R. Paul Ross,Paul W. O' Toole +8 more
TL;DR: The genome of L. ruminis provides a comparative tool for directing functional analyses of other members of the L. salivarius clade, and it increases understanding of the divergence of this distinct Lactobacillus lineage from other commensal lactobacilli.
Journal ArticleDOI
Carbohydrate catabolic flexibility in the mammalian intestinal commensal Lactobacillus ruminis revealed by fermentation studies aligned to genome annotations
Michelle M O’ Donnell,Michelle M O’ Donnell,Brian M. Forde,B Neville,Paul Ross,Paul W. O' Toole +5 more
TL;DR: This study has provided definitive genome-based evidence to support the fermentation patterns of nine strains of Lactobacillus ruminis, and has linked it to gene distribution patterns in strains from different sources.
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The gut microbiota composition in dichorionic triplet sets suggests a role for host genetic factors.
Kiera Murphy,Carol Anne O’ Shea,C. Anthony Ryan,Eugene M. Dempsey,Paul W. O' Toole,Catherine Stanton,R. Paul Ross +6 more
TL;DR: It is hypothesized that initially host genetics play a significant role in the composition of an individual’s gut microbiota, unless an antibiotic intervention is given, but by month 12 environmental factors are the major determinant.