Paula Toni Del Giudice

TL;DR: In this article, the effect of varicocele on sperm DNA integrity, mitochondrial activity, lipid peroxidation, and acrosome integrity was evaluated in 30 patients with and 32 men without the condition.

TL;DR: This study was able to demonstrate that varicocelectomy in adolescents is associated with increased sperm DNA integrity and mitochondrial activity, however, levels of seminal products of lipid degradation (malondialdehyde) are not different.

TL;DR: Changes in the proteomic profile of adolescents with varicocele and normal semen parameters (VNS group) indicate that normal semen analysis may not reflect alterations in proteins in seminal plasma, which will facilitate detection of new proteins associated with spermatogenesis and sperm function.

TL;DR: While semen processing selects sperm with higher rates of DNA integrity independent of the presence or absence of leukocytes in semen, samples without leukocytospermia present more sperm without DNA fragmentation.

TL;DR: Processes such as triacylglycerol metabolism, energy production, protein folding, response to unfolded proteins, and cellular detoxification were found to be altered in these cells.