A survey on deep learning in medical image analysis

Generative adversarial network in medical imaging: A review.

The remarkable advances in biotechnology and health sciences have led to a significant production of data, such as high throughput genetic data and clinical information, generated from large Electronic Health Records (EHRs). To this end, application of machine learning and data mining methods in biosciences is presently, more than ever before, vital and indispensable in efforts to transform intelligently all available information into valuable knowledge. Diabetes mellitus (DM) is defined as a group of metabolic disorders exerting significant pressure on human health worldwide. Extensive research in all aspects of diabetes (diagnosis, etiopathophysiology, therapy, etc.) has led to the generation of huge amounts of data. The aim of the present study is to conduct a systematic review of the applications of machine learning, data mining techniques and tools in the field of diabetes research with respect to a) Prediction and Diagnosis, b) Diabetic Complications, c) Genetic Background and Environment, and e) Health Care and Management with the first category appearing to be the most popular. A wide range of machine learning algorithms were employed. In general, 85% of those used were characterized by supervised learning approaches and 15% by unsupervised ones, and more specifically, association rules. Support vector machines (SVM) arise as the most successful and widely used algorithm. Concerning the type of data, clinical datasets were mainly used. The title applications in the selected articles project the usefulness of extracting valuable knowledge leading to new hypotheses targeting deeper understanding and further investigation in DM.

Machine Learning and Data Mining Methods in Diabetes Research.

Artificial intelligence (AI) based on deep learning (DL) has sparked tremendous global interest in recent years. DL has been widely adopted in image recognition, speech recognition and natural language processing, but is only beginning to impact on healthcare. In ophthalmology, DL has been applied to fundus photographs, optical coherence tomography and visual fields, achieving robust classification performance in the detection of diabetic retinopathy and retinopathy of prematurity, the glaucoma-like disc, macular oedema and age-related macular degeneration. DL in ocular imaging may be used in conjunction with telemedicine as a possible solution to screen, diagnose and monitor major eye diseases for patients in primary care and community settings. Nonetheless, there are also potential challenges with DL application in ophthalmology, including clinical and technical challenges, explainability of the algorithm results, medicolegal issues, and physician and patient acceptance of the AI ‘black-box’ algorithms. DL could potentially revolutionise how ophthalmology is practised in the future. This review provides a summary of the state-of-the-art DL systems described for ophthalmic applications, potential challenges in clinical deployment and the path forward.

https://bjo.bmj.com/content/bjophthalmol/103/2/167.full.pdf

Artificial intelligence and deep learning in ophthalmology

Automated medical image analysis is an emerging field of research that identifies the disease with the help of imaging technology. Diabetic retinopathy (DR) is a retinal disease that is diagnosed in diabetic patients. Deep neural network (DNN) is widely used to classify diabetic retinopathy from fundus images collected from suspected persons. The proposed DR classification system achieves a symmetrically optimized solution through the combination of a Gaussian mixture model (GMM), visual geometry group network (VGGNet), singular value decomposition (SVD) and principle component analysis (PCA), and softmax, for region segmentation, high dimensional feature extraction, feature selection and fundus image classification, respectively. The experiments were performed using a standard KAGGLE dataset containing 35,126 images. The proposed VGG-19 DNN based DR model outperformed the AlexNet and spatial invariant feature transform (SIFT) in terms of classification accuracy and computational time. Utilization of PCA and SVD feature selection with fully connected (FC) layers demonstrated the classification accuracies of 92.21%, 98.34%, 97.96%, and 98.13% for FC7-PCA, FC7-SVD, FC8-PCA, and FC8-SVD, respectively.

Fundus Image Classification Using VGG-19 Architecture with PCA and SVD

Automatic segmentation of blood vessels in fundus images is of great importance as eye diseases as well as some systemic diseases cause observable pathologic modifications. It is a binary classification problem: for each pixel we consider two possible classes (vessel or non-vessel). We use a GPU implementation of deep max-pooling convolutional neural networks to segment blood vessels. We test our method on publiclyavailable DRIVE dataset and our results demonstrate the high effectiveness of the deep learning approach. Our method achieves an average accuracy and AUC of 0.9466 and 0.9749, respectively.

/pdf/retinal-vessel-segmentation-using-deep-neural-networks-1fu8mnyndw.pdf

Retinal Vessel Segmentation Using Deep Neural Networks

Detection of exudates in fundus photographs using deep neural networks and anatomical landmark detection fusion

Accurate segmentation of the retinal microvasculature is a critical step in the quantitative analysis of the retinal circulation, which can be an important marker in evaluating the severity of retinal diseases. As manual segmentation remains the gold standard for segmentation of optical coherence tomography angiography (OCT-A) images, we present a method for automating the segmentation of OCT-A images using deep neural networks (DNNs). Eighty OCT-A images of the foveal region in 12 eyes from 6 healthy volunteers were acquired using a prototype OCT-A system and subsequently manually segmented. The automated segmentation of the blood vessels in the OCT-A images was then performed by classifying each pixel into vessel or nonvessel class using deep convolutional neural networks. When the automated results were compared against the manual segmentation results, a maximum mean accuracy of 0.83 was obtained. When the automated results were compared with inter and intrarater accuracies, the automated results were shown to be comparable to the human raters suggesting that segmentation using DNNs is comparable to a second manual rater. As manually segmenting the retinal microvasculature is a tedious task, having a reliable automated output such as automated segmentation by DNNs, is an important step in creating an automated output.

https://www.spiedigitallibrary.org/journals/Journal-of-Biomedical-Optics/volume-21/issue-7/075008/Segmentation-of-the-foveal-microvasculature-using-deep-learning-networks/10.1117/1.JBO.21.7.075008.pdf

Segmentation of the foveal microvasculature using deep learning networks.

Diabetic retinopathy is one of the leading disabling chronic diseases, and one of the leading causes of preventable blindness in the world Early diagnosis of diabetic retinopathy enables timely treatment and in order to achieve it a major effort will have to be invested into screening programs and especially into automated screening programs For automated screening programs to work robustly a representative fundus image database is required In this paper we give an overview of currently available databases and present a new diabetic retinopathy database Our database is to our knowledge the first and only database which has diabetic retinopathy pathologies and major fundus structures annotated for every image from the database which makes it perfect for design and evaluation of currently available and new image processing algorithms for early detection of diabetic retinopathy using color fundus images

Diabetic retinopathy image database(DRiDB): A new database for diabetic retinopathy screening programs research

Diabetic retinopathy is one of the leading causes of preventable blindness in the developed world. Early diagnosis of diabetic retinopathy enables timely treatment and in order to achieve it a major effort will have to be invested into screening programs and especially into automated screening programs. Detection of exudates is very important for early diagnosis of diabetic retinopathy. Deep neural networks have proven to be a very promising machine learning technique, and have shown excellent results in different compute vision problems. In this paper we show that convolutional neural networks can be effectively used in order to detect exudates in color fundus photographs.

Pavle Prentasic

Papers

Retinal Vessel Segmentation Using Deep Neural Networks

Detection of exudates in fundus photographs using deep neural networks and anatomical landmark detection fusion

Segmentation of the foveal microvasculature using deep learning networks.

Diabetic retinopathy image database(DRiDB): A new database for diabetic retinopathy screening programs research

Detection of exudates in fundus photographs using convolutional neural networks