P
Pearl A. Campbell
Researcher at Ottawa Hospital Research Institute
Publications - 17
Citations - 1777
Pearl A. Campbell is an academic researcher from Ottawa Hospital Research Institute. The author has contributed to research in topics: Cellular differentiation & Embryonic stem cell. The author has an hindex of 9, co-authored 16 publications receiving 1664 citations. Previous affiliations of Pearl A. Campbell include Ontario Genomics Institute & Johns Hopkins University.
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Journal ArticleDOI
Cytidine methylation of regulatory sequences near the pi-class glutathione S-transferase gene accompanies human prostatic carcinogenesis
Wen-Hsiang Lee,Ronald A. Morton,Jonathan I. Epstein,James D. Brooks,Pearl A. Campbell,G S Bova,Wen Son Hsieh,William B. Isaacs,William G. Nelson +8 more
TL;DR: Methylation of cytidine nucleotides in GSTP1 regulatory sequences constitutes the most common genomic alteration yet described for human prostate cancer.
Journal ArticleDOI
Transfer of microRNA-486-5p from human endothelial colony forming cell-derived exosomes reduces ischemic kidney injury.
Jose L. Viñas,Dylan Burger,Joseph Zimpelmann,Randa Haneef,William Knoll,Pearl A. Campbell,Alex Gutsol,Anthony Carter,David S. Allan,Kevin D. Burns +9 more
TL;DR: In mice with ischemic kidney injury, infusion of ECFC exosomes induced potent functional and histologic protection, associated with increased kidney miR-486-5p levels, decreased PTEN, and activation of Akt.
Journal Article
Phenylbutyrate induces apoptosis in human prostate cancer and is more potent than phenylacetate.
Michael A. Carducci,Joel B. Nelson,Kirk M. Chan-Tack,Sujatha R. Ayyagari,William H. Sweatt,Pearl A. Campbell,William G. Nelson,Jonathan W. Simons +7 more
TL;DR: It is found that PB is more potent than PA in vitro; PB is 1.5-2.5 times more active at inhibiting growth and inducing programmed cell death than PA at clinically achievable doses against each human prostate cancer line studied.
Journal ArticleDOI
Gene function in early mouse embryonic stem cell differentiation
Kagnew Hailesellasse Sene,Christopher J. Porter,Gareth A. Palidwor,Carolina Perez-Iratxeta,Enrique M. Muro,Pearl A. Campbell,Michael A. Rudnicki,Miguel A. Andrade-Navarro +7 more
TL;DR: Analysis profiles for the first time gene expression at a very early stage of mouse embryonic stem cell differentiation are generated, and a functional and phylogenetic signature for the genes involved is identified.
Journal ArticleDOI
Phenotypic and genotypic characteristics of aberrant crypt foci in human colorectal mucosa.
TL;DR: The findings suggest that "aberrant crypt focus" is a generic term analogous to "polyp" and requires further histopathologic, phenotypic, or genotypic classification into dysplastic and heteroplastic types.