Showing papers by "Peggy Dartigues published in 2013"
TL;DR: Retroperitoneal lymph node recurrence seems to be linked to OM originating from colorectal cancer and could worsen the prognosis and study its potential benefit on survival.
Abstract: To analyze the patterns of recurrence and the prognostic impact of ovarian metastases (OM) in a population of women with colorectal peritoneal carcinomatosis (CRPC) treated with curative intent. Data from all consecutive women with CRPC who underwent curatively intended complete cytoreductive surgery (CRS) plus intraperitoneal chemotherapy at our institution were retrieved from a prospective database. A bilateral oophorectomy or a complementary unilateral oophorectomy was systematically performed during CRS. From 1994 to 2009, among 105 women who underwent CRS plus intraperitoneal chemotherapy for CRPC, 62 (60 %) had OM. Women with and without OM had comparable peritoneal cancer index (PCI) scores (10 vs. 12, respectively, p = 0.09). After a median follow-up of 60 (range 5–145) months, median overall survival of women with OM did not differ statistically from that of women without OM (respectively, 36 and 40 months; p = 0.75). Relapses occurred in 82 % of the patients, distributed similarly between the two groups except for retroperitoneal lymph node recurrence, which occurred in 19 patients (18 %), including 18 with OM. The only predictive factor for a retroperitoneal relapse was a history of OM (p = 0.0012). Retroperitoneal lymph node recurrence seems to be linked to OM originating from colorectal cancer and could worsen the prognosis. A systematic lymphadenectomy could be evaluated in women with isolated OM or very limited peritoneal carcinomatosis to analyze the incidence of invaded lymph nodes and study its potential benefit on survival.
15 citations
TL;DR: The detection of CPALN on CT may be of valuable help for the diagnosis of PC in patients with CRC, according to a retrospectively reviewed preoperative CT scans.
15 citations
TL;DR: A new policy to preserve the ovaries when they were macroscopically normal in young women with PC of different origin who expressed a strong desire for future pregnancy allowed ovarian preservation in 44 % of the young women wishing childbearing and allowed two births.
Abstract: Objective
To appreciate if the ovaries can be preserved in selected young women with peritoneal carcinomatosis (PC).
10 citations
TL;DR: A new policy to preserve the ovaries when they are macroscopically normal in young women with peritoneal pseudomyxoma allowed ovarian preservation in 43% of the young women desiring a future pregnancy and has already resulted in one birth.
Abstract: Objective To determine whether ovaries can be preserved in selected young women with peritoneal pseudomyxoma (PMP). Background data The traditional rule is to systematically perform a bilateral oophorectomy. Patients and methods A new policy was developed to preserve the ovaries when they are macroscopically normal in young women with PMP, strongly desiring a future pregnancy. Results Thirty-three women younger than 41 years were selected after undergoing complete cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy for PMP. A normal ovary was preserved in 6 of them, but in 6 of the 14 women who strongly desired a future pregnancy. Subsequently, ovarian preservation was only performed in cases of grade-1 PMP. Ovarian invasion was correlated with the grade (p Conclusion This new policy allowed ovarian preservation in 43% of the young women desiring a future pregnancy and has already resulted in one birth. It exclusively concerned low-grade PMP. Recurrence in the preserved ovary was 0% with our selection criteria.
8 citations
TL;DR: PET performed after 2 cycles of chemotherapy (PET2) might identify early responding patients able to benefit from a strategy of dose intensity decrease after upfront BEAesc, without impairing the disease control.
Abstract: TPS8615 Background: ABVD is the most widely chemotherapy regimen used as standard treatment of advanced Hodgkin lymphoma (HL). The escalated BEACOPP (BEAesc) regimen which delivers more drugs at hi...
6 citations