P
Pei Chen
Researcher at Boston Children's Hospital
Publications - 18
Citations - 1284
Pei Chen is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Ulcerative colitis & Anxiety. The author has an hindex of 15, co-authored 18 publications receiving 1099 citations. Previous affiliations of Pei Chen include Partners HealthCare & Harvard University.
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Journal ArticleDOI
Normalization of plasma 25-hydroxy vitamin D is associated with reduced risk of surgery in Crohn's disease.
Ashwin N. Ananthakrishnan,Andrew Cagan,Vivian S. Gainer,Tianxi Cai,Su Chun Cheng,Guergana Savova,Pei Chen,Peter Szolovits,Zongqi Xia,Zongqi Xia,Philip L. De Jager,Philip L. De Jager,Stanley Y. Shaw,Susanne Churchill,Elizabeth W. Karlson,Elizabeth W. Karlson,Isaac S. Kohane,Isaac S. Kohane,Isaac S. Kohane,Robert M. Plenge,Robert M. Plenge,Shawn N. Murphy,Shawn N. Murphy,Katherine P. Liao,Katherine P. Liao +24 more
TL;DR: In this paper, the authors suggest that vitamin D may have an immunological role in Crohn's disease (CD) and ulcerative colitis (UC) and that there is a weak association between vitamin D status and disease activity but have significant limitations.
Journal ArticleDOI
Improving case definition of Crohn's disease and ulcerative colitis in electronic medical records using natural language processing: a novel informatics approach.
Ashwin N. Ananthakrishnan,Tianxi Cai,Guergana Savova,Su Chun Cheng,Pei Chen,Raul Guzman Perez,Vivian S. Gainer,Shawn N. Murphy,Shawn N. Murphy,Peter Szolovits,Zongqi Xia,Zongqi Xia,Stanley Y. Shaw,Susanne Churchill,Elizabeth W. Karlson,Elizabeth W. Karlson,Isaac S. Kohane,Isaac S. Kohane,Isaac S. Kohane,Robert M. Plenge,Robert M. Plenge,Katherine P. Liao,Katherine P. Liao +22 more
TL;DR: Inclusion of narrative concepts identified using natural language processing improves the accuracy of electronic medical records case definition for CD and UC while simultaneously identifying more subjects compared with models using codified data alone.
Journal ArticleDOI
Normalization and standardization of electronic health records for high-throughput phenotyping: the SHARPn consortium
Jyotishman Pathak,Kent R. Bailey,Calvin E. Beebe,Steven Bethard,David Carrell,Pei Chen,Dmitriy Dligach,Cory M. Endle,Lacey A. Hart,Peter J. Haug,Stanley M. Huff,Vinod C. Kaggal,Dingcheng Li,Hongfang Liu,Kyle Marchant,James J. Masanz,Timothy A. Miller,Thomas A. Oniki,Martha Palmer,Kevin J. Peterson,Susan Rea,Guergana Savova,Craig Stancl,Sunghwan Sohn,Harold R. Solbrig,Dale Suesse,Cui Tao,David P. Taylor,Les Westberg,Stephen Wu,Ning Zhuo,Christopher G. Chute +31 more
TL;DR: A data-normalization platform that ensures data security, end-to-end connectivity, and reliable data flow within and across institutions is developed and demonstrated by executing a QDM-based MU quality measure that determines the percentage of patients between 18 and 75 years with diabetes whose most recent low-density cholesterol test result during the measurement year was <100 mg/dL.
Improving Case Definition of Crohnʼs Disease and Ulcerative Colitis in Electronic Medical Records Using Natural Language Processing
Ashwin N. Ananthakrishnan,Tianxi Cai,Guergana Savova,Su-Chun Cheng,Pei Chen,Raul Guzman Perez,Vivian S. Gainer,Shawn N. Murphy,Peter Szolovits,Zongqi Xia,Stanley Y. Shaw,Susanne Churchill,Elizabeth W. Karlson,Isaac S. Kohane,Robert M. Plenge,Katherine P. Liao +15 more
TL;DR: In this article, the authors developed a robust electronic medical record-based model for classification of inflammatory bowel disease leveraging the combination of codified data and information from clinical text notes using natural language processing.
Journal ArticleDOI
Psychiatric co-morbidity is Associated with Increased risk of Surgery in Crohn’s disease
Ashwin N. Ananthakrishnan,Vivian S. Gainer,Raul Guzman Perez,Tianxi Cai,Su Chun Cheng,Guergana Savova,Pei Chen,Peter Szolovits,Zongqi Xia,Zongqi Xia,P. L. De Jager,P. L. De Jager,Stanley Y. Shaw,Susanne Churchill,Elizabeth W. Karlson,Elizabeth W. Karlson,Isaac S. Kohane,Isaac S. Kohane,Isaac S. Kohane,Roy H. Perlis,Robert M. Plenge,Robert M. Plenge,Shawn N. Murphy,Shawn N. Murphy,Katherine P. Liao,Katherine P. Liao +25 more
TL;DR: Psychiatric co‐morbidity, in particular major depression and anxiety, is common in patients with Crohn's disease and ulcerative colitis and prior studies examining this may be confounded by the co‐existence of functional bowel symptoms.