P
Perumal Subramanian
Researcher at Annamalai University
Publications - 143
Citations - 2184
Perumal Subramanian is an academic researcher from Annamalai University. The author has contributed to research in topics: Lipid peroxidation & Glutathione peroxidase. The author has an hindex of 24, co-authored 138 publications receiving 1973 citations. Previous affiliations of Perumal Subramanian include Madurai Kamaraj University & Indian Institute of Technology Madras.
Papers
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Journal ArticleDOI
Circadian disruption accelerates liver carcinogenesis in mice.
Elisabeth Filipski,Perumal Subramanian,Perumal Subramanian,Jennyfer Carrière,Jennyfer Carrière,Catherine Guettier,Hervé Barbason,Hervé Barbason,Francis Lévi,Francis Lévi +9 more
TL;DR: The association of circadian disruption with chronic DEN exposure suggests that circadian clocks actively control the mechanisms of liver carcinogenesis in mice and may further be critical for slowing down and/or reverting cancer development after carcinogen exposure.
Journal ArticleDOI
Naringenin (citrus flavonone) induces growth inhibition, cell cycle arrest and apoptosis in human hepatocellular carcinoma cells.
D. Arul,Perumal Subramanian +1 more
TL;DR: Naringenin was shown to inhibit the proliferation of HepG2 cells resulted partly from an accumulation of cells in the G0/G1 and G2/M phase of the cell cycle, and triggered the mitochondrial-mediated apoptosis pathway.
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Morin a flavonoid exerts antioxidant potential in chronic hyperammonemic rats: a biochemical and histopathological study
TL;DR: Findings indicate that morin exert antioxidant potential and offer protection against ammonium chloride-induced hyperammonemia, but the exact underlying mechanism needs to be elucidated.
Journal Article
S-allylcysteine inhibits circulatory lipid peroxidation and promotes antioxidants in N-nitrosodiethylamine-induced carcinogenesis.
TL;DR: It is suggested that SAC exerts its chemopreventive effects by decreasing lipid peroxidation and enhancing the levels of antioxidants in NDEA carcinogenesis by reducing the formation of free radicals.
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Effects of α-ketoglutarate on antioxidants and lipid peroxidation products in rats treated with ammonium acetate
TL;DR: The biochemical alterations during alpha-KG treatment might have been due to 1) the detoxification of excess ammonia, 2) participation in the non-enzymatic oxidative decarboxylation during hydrogen peroxide decomposition, and 3) enhancement of the proper metabolism of fats that could suppress oxygen radical generation and thus prevent lipid peroxidative damages in rats.