Peter C G Nijssen

TL;DR: The findings suggest that STN could be the preferred target for DBS in patients with advanced Parkinson's disease, and no statistically significant difference was found in either of the primary outcomes.

TL;DR: In this article, the authors evaluated the cognitive and behavioral effects of bilateral subthalamic nucleus (STN) stimulation in patients with Parkinson disease (PD) 6 months after surgery and found that the STN group showed a larger decline than the control group on measures of verbal fluency, color naming, selective attention, and verbal memory.

TL;DR: In this article, the authors compared the efficacy of unilateral pallidotomy and bilateral subthalamic nucleus (STN) stimulation in patients with advanced Parkinson disease (PD) in a randomized, observer-blind, multicenter trial.

TL;DR: This work identified in five individuals one of two disease-causing mutations, c.346_348delCTC and c.344T>G, in DNAJC5 encoding cysteine-string protein alpha (CSPα), which confirms a neuroprotective role for CSPα in humans and demonstrates the need for detailed investigation of CSP α in the neuronal ceroid lipofuscinoses and other neurodegenerative diseases presenting with neuronal protein aggregation.

TL;DR: Evidence is affirms that exposure to herbicides and insecticides increase the risk of PD and future studies should focus on more objective and improved methods of pesticide exposure assessment.