Peter Diamond

TL;DR: It is proposed that inhibition of the CXCR4-SDF-1α axis may provide an effective means of treatment for MM-induced osteolysis and serve to recruit osteoclast precursors to local sites within the bone marrow and enhance their motility and bone-resorbing activity.

TL;DR: Using retroviral expression cloning, it is determined that STRO-3 binds to tissue nonspecific alkaline phosphatase (TNSALP), a cell-surface glycoprotein usually associated with cells of the osteoblast lineage that may represent a marker of immature BMSSCs in vivo.

TL;DR: The emerging role of hypoxia and the HIFs in the pathogenesis of multiple myeloma (MM), an incurable hematological malignancy of BM PCs, which reside within the hypoxic BM microenvironment is discussed.

TL;DR: The identification of complexes, binding to the VEGFmRNA 5'- and 3'-UTR, that contain cold shock domain (CSD) and polypyrimidine tract binding (PTB) RNA binding proteins are reported, suggesting a combined transcriptional/post-transcriptional role for these proteins in V EGF and other growth factor gene regulation.

TL;DR: It is shown that dasatinib increases trabecular bone volume at least in part by inhibiting osteoclast activity, suggesting that d asatinib therapy may result in dysregulated bone remodeling.