Peter Gute

TL;DR: The incidence of AIDS-defining events in patients with advanced HIV infection at Frankfurt University Hospital has declined by more than 70% from 1992 to 1996, with a trend for malignancies and single opportunistic infections, with the exception of mycobacterial diseases.

TL;DR: Changes in surrogate markers suggest that treatment provided benefit in spite of virological failure and resistant virus, and patients with a shift to wild type virus responded better in the short term to treatment re-initiation.

TL;DR: The results strongly support a direct causal relationship between HIV replication and CD4 lymphocyte count depletion and the rise in those with > 3 log suppression provides the best available indicator of the potential for natural CD4 regeneration in HIV-infected patients.

TL;DR: It is suggested that transmission of HIV-1 can occur despite undetectable pVL, and should be added to the discussion of prevention strategies, which should not advise the abandonment of safer-sex practices without referring to the relatively low but not impossible risk of virus transmission in this context.

TL;DR: In this retrospective analysis based on a small number of patients, viral drug susceptibility at baseline was strongly associated with virological outcome at 24 weeks, independent of covariates such as baseline viral load and treatment history.