A
Alessandro Cozzi-Lepri
Researcher at University College London
Publications - 227
Citations - 9323
Alessandro Cozzi-Lepri is an academic researcher from University College London. The author has contributed to research in topics: Viral load & Medicine. The author has an hindex of 44, co-authored 194 publications receiving 8237 citations. Previous affiliations of Alessandro Cozzi-Lepri include University of Siena & Imperial College London.
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Journal ArticleDOI
A Whole-Genome Association Study of Major Determinants for Host Control of HIV-1
Jacques Fellay,Kevin V. Shianna,Dongliang Ge,Sara Colombo,Bruno Ledergerber,Michael E. Weale,Kunlin Zhang,Curtis Gumbs,Antonella Castagna,Andrea Cossarizza,Alessandro Cozzi-Lepri,Andrea De Luca,Philippa Easterbrook,P Francioli,Simon Mallal,Javier Martinez-Picado,José M. Miró,Niels Obel,Jason Smith,Josiane Wyniger,Patrick Descombes,Stylianos E. Antonarakis,Norman L. Letvin,Andrew J. McMichael,Barton F. Haynes,Amalio Telenti,David Goldstein +26 more
TL;DR: Using a whole-genome association strategy, polymorphisms that explain nearly 15% of the variation among individuals in viral load during the asymptomatic set-point period of infection are identified.
Journal ArticleDOI
Tocilizumab in patients with severe COVID-19: a retrospective cohort study
Giovanni Guaraldi,Marianna Meschiari,Alessandro Cozzi-Lepri,Jovana Milic,Roberto Tonelli,Marianna Menozzi,Erica Franceschini,Gianluca Cuomo,Gabriella Orlando,Vanni Borghi,Antonella Santoro,Margherita Di Gaetano,Cinzia Puzzolante,Federica Carli,Andrea Bedini,Luca Corradi,Riccardo Fantini,Ivana Castaniere,Luca Tabbì,Massimo Girardis,Sara K. Tedeschi,Maddalena Giannella,Michele Bartoletti,Renato Pascale,Giovanni Dolci,Lucio Brugioni,Antonello Pietrangelo,Andrea Cossarizza,Federico Pea,Enrico Clini,Carlo Salvarani,Marco Massari,Pierluigi Viale,Cristina Mussini +33 more
TL;DR: Assessment of the role of tocilizumab in reducing the risk of invasive mechanical ventilation and death in patients with severe COVID-19 pneumonia who received standard of care treatment found it to be associated with a reduced risk.
Journal Article
Common Genetic Variation and the Control of HIV-1 in Humans
Jacques Fellay,Dongliang Ge,Kevin V. Shianna,Sara Colombo,Bruno Ledergerber,Elizabeth T. Cirulli,Thomas J. Urban,Kunlin Zhang,Curtis Gumbs,Jason Smith,Antonella Castagna,Alessandro Cozzi-Lepri,Andrea De Luca,Philippa Easterbrook,Huldrych F. Günthard,Simon Mallal,Cristina Mussini,Judith Dalmau,Javier Martinez-Picado,José M. Miró,Niels Obel,Steven M. Wolinsky,Jeremy J. Martinson,Roger Detels,Joseph B. Margolick,Lisa P. Jacobson,Patrick Descombes,Stylianos E. Antonarakis,Jacques S. Beckmann,Stephen J. O'Brien,Norman L. Letvin,Andrew J. McMichael,Barton F. Haynes,Mary Carrington,Sheng Feng,Amalio Telenti,David Goldstein,Aids Vaccine Immunology +37 more
TL;DR: The authors performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects and found common genetic variants explaining down to 1.3% of the variability in viral load at set point.
Journal ArticleDOI
Common genetic variation and the control of HIV-1 in humans.
Jacques Fellay,Dongliang Ge,Kevin V. Shianna,Sara Colombo,Bruno Ledergerber,Elizabeth T. Cirulli,Thomas J. Urban,Kunlin Zhang,Curtis Gumbs,Jason Smith,Antonella Castagna,Alessandro Cozzi-Lepri,Andrea De Luca,Philippa J. Easterbrook,Huldrych F. Günthard,Simon Mallal,Cristina Mussini,Judith Dalmau,Javier Martinez-Picado,José M. Miró,Niels Obel,Steven M. Wolinsky,Jeremy J. Martinson,Roger Detels,Joseph B. Margolick,Lisa P. Jacobson,Patrick Descombes,Stylianos E. Antonarakis,Jacques S. Beckmann,Stephen J. O'Brien,Norman L. Letvin,Andrew J. McMichael,Barton F. Haynes,Mary Carrington,Mary Carrington,Sheng Feng,Amalio Telenti,David Goldstein +37 more
TL;DR: This study provides overwhelming confirmation of three associations previously reported in a genome-wide study and shows further independent effects of both common and rare variants in the Major Histocompatibility Complex region (MHC).
Journal ArticleDOI
Effect of transmitted drug resistance on virological and immunological response to initial combination antiretroviral therapy for HIV (EuroCoord-CHAIN joint project): a European multicohort study
Linda Wittkop,Huldrych F. Günthard,Frank de Wolf,David Dunn,Alessandro Cozzi-Lepri,Alessandro Cozzi-Lepri,Andrea De Luca,Andrea De Luca,Claudia Kücherer,Niels Obel,Viktor von Wyl,Bernard Masquelier,Christoph Stephan,Carlo Torti,Andrea Antinori,Federico García,Ali Judd,Kholoud Porter,Rodolphe Thiébaut,Hannah Castro,Ard van Sighem,Céline Colin,Jesper Kjaer,Jens D Lundgren,Roger Paredes,Anton Pozniak,Bonaventura Clotet,Andrew N. Phillips,Deenan Pillay,Geneviève Chêne +29 more
TL;DR: Findings confirm present treatment guidelines for HIV, which state that the initial treatment choice should be based on resistance testing in treatment-naive patients, that the effect of TDR on outcome in the first year of cART is confirmed.