Some of the relevant features of the clinical pharmacology of the tetracycline antibiotics are reviewed, and, in particular, the absorption, excretion, and disposition in the body of the four homologues that are currently available for clinical use are compared. The relatively minor differences in the chemical structure of these drugs are accompanied by significant differences in some of their physical properties and by some quantitative differences in their absorption, excretion, and distribution in the body, their activity against different bacteria, and their clinical toxicity.

Clinical pharmacology of the tetracycline antibiotics.

The Global Burden of Cardiovascular Diseases and Risk: A Compass for Future Health.

Antibiotic-resistant staphylococcal infection a study of antibiotic sensitivity in relation to bacteriophage types

Initial treatment with a single pill containing quadruple combination of quarter doses of blood pressure medicines versus standard dose monotherapy in patients with hypertension (QUARTET): a phase 3, randomised, double-blind, active-controlled trial.

Long-term efficacy and safety of moderate-intensity statin with ezetimibe combination therapy versus high-intensity statin monotherapy in patients with atherosclerotic cardiovascular disease (RACING): a randomised, open-label, non-inferiority trial

Peter Hay

Papers

Initial treatment with a single pill containing quadruple combination of quarter doses of blood pressure medicines versus standard dose monotherapy in patients with hypertension (QUARTET): a phase 3, randomised, double-blind, active-controlled trial.

Side-effects of oxytetracycline therapy.

Ultra-low-dose quadruple combination blood pressure-lowering therapy in patients with hypertension: The QUARTET randomized controlled trial protocol

Pneumothorax complicating intermittent positive-pressure respiration.