P
Peter Heukels
Researcher at Erasmus University Rotterdam
Publications - 11
Citations - 309
Peter Heukels is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Idiopathic pulmonary fibrosis & Pulmonary fibrosis. The author has an hindex of 4, co-authored 9 publications receiving 157 citations. Previous affiliations of Peter Heukels include Erasmus University Medical Center.
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Journal ArticleDOI
Inflammation and immunity in IPF pathogenesis and treatment
TL;DR: The role of the innate and adaptive immune system in the initiation and perpetuation of IPF pathobiology is focused on and how immune responses are influenced by current anti-fibrotic treatments, such as pirfenidone and nintedanib are discussed.
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Fibrocytes are increased in lung and peripheral blood of patients with idiopathic pulmonary fibrosis
Peter Heukels,J. A. C. van Hulst,M. van Nimwegen,Carian E. Boorsma,Barbro N. Melgert,L M van den Toorn,K. A. Boomars,Marlies S. Wijsenbeek,Henk C. Hoogsteden,J. Von Der Thüsen,Rudolf W. Hendriks,Mirjam Kool,B. van den Blink +12 more
TL;DR: It is shown that patients with IPF have increased proportions of fibrocytes, not only in the circulation, but also in explanted end-stage IPF lungs, using a gating strategy that excludes potentially contaminating cell populations.
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Enhanced Bruton's tyrosine kinase in B-cells and autoreactive IgA in patients with idiopathic pulmonary fibrosis
Peter Heukels,Jennifer A C van Hulst,Menno van Nimwegen,Carian E. Boorsma,Barbro N. Melgert,Barbro N. Melgert,Jan H. von der Thüsen,Bernt van den Blink,Rogier A.S. Hoek,Jelle R. Miedema,Stefan F H Neys,Odilia B. J. Corneth,Rudi W. Hendriks,Marlies S. Wijsenbeek,Mirjam Kool +14 more
TL;DR: It is demonstrated that IPF patients have more circulating activated B-cells and autoreactive IgA, which correlate with disease progression, which could be useful as a biomarker for disease progression in IPF.
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Integrating patient perspectives into personalized medicine in idiopathic pulmonary fibrosis
TL;DR: This review describes recent insights and methods on how to integrate patient perspectives into personalized medicine and provides an overview of the most used patient-reported outcome measures in IPF to facilitate choices for both researchers and clinicians when incorporating the patient voice in their research and care.
Journal ArticleDOI
Plasma markers in pulmonary hypertension subgroups correlate with patient survival
Thomas Koudstaal,D. van Uden,J. A. C. van Hulst,Peter Heukels,Ingrid M. Bergen,Laurie W Geenen,Vivan J.M. Baggen,A E Van Den Bosch,L M van den Toorn,Prewesh Chandoesing,Mirjam Kool,Eric Boersma,Rudolf W. Hendriks,K. A. Boomars +13 more
TL;DR: In this paper, the authors investigated whether the inflammatory profile of pulmonary hypertension patients changes over time and correlates with patient WHO subgroups or survival, and they found that increased CXCL9 and IL-8 concentrations in CETPH patients correlated significantly with decreased survival.