Peter J. Greasley

TL;DR: This review summarizes current data indicating the extent to which cannabinoid receptor ligands undergo orthosteric or allosteric interactions with non- CB1, non-CB2 established GPCRs, deorphanized receptors such as GPR55, ligand-gated ion channels, transient receptor potential (TRP) channels, and other ion channels or peroxisome proliferator-activated nuclear receptors.

TL;DR: The endocannabinoid system functions through two well characterized receptor systems, the CB1 and CB2 receptors, and work by a number of groups in recent years has provided evidence that the system is more complicated and additional receptor types should exist to explain ligand activity in anumber of physiological processes.

TL;DR: In this paper, the authors demonstrate that GPR55 is a novel cannabinoid receptor and its ligand profile with respect to CB 1 and CB 2 described here will permit delineation of its physiological function(s).

TL;DR: It is hypothesized that, by reducing IF volume to a greater extent than blood volume, SGLT2 inhibitors might provide better control of congestion without reducing arterial filling and perfusion.

TL;DR: In this paper, the role of G protein-coupled receptor (GPR55) in bone biology was examined in both human and mouse osteoclasts and osteoblasts.