Peter Kurtzhals

TL;DR: The combination of the B31B32diArg and A21Gly substitutions provided insulin glargine with a 6- to 8-fold increased IGF-I receptor affinity and mitogenic potency compared with human insulin, and the reduced in vitro potency of insulin detemir might explain why this analog is not as effective on a molar basis as human insulin in humans.

TL;DR: Intravenous kinetic studies showed that the clearance and volume of distribution decreased with increasing albumin binding affinity of different acylated insulin analogs, enabling increased predictability of basal insulin.

TL;DR: It is concluded that the biochemical concept of albumin binding can be applied to protract the effect of insulin, and suggested that derivatization with albumin-binding ligands could be generally applicable to prolong the action profile of peptide drugs.

TL;DR: LysB29-tetradecanoyl des-(B30) insulin might be suitable for providing basal insulin in the treatment of diabetes mellitus, because it does not elicit invasion of macrophages at the site of injection.

TL;DR: A novel class of GSK-3 inhibitors with favorable water solubility was identified in a HTS screen and a 3-fold stimulation of the glycogen synthesis in rat soleus muscle was obtained, comparable to the maximal stimulation by insulin itself.