Claus Kristensen

TL;DR: The combination of the B31B32diArg and A21Gly substitutions provided insulin glargine with a 6- to 8-fold increased IGF-I receptor affinity and mitogenic potency compared with human insulin, and the reduced in vitro potency of insulin detemir might explain why this analog is not as effective on a molar basis as human insulin in humans.

TL;DR: The most striking finding is that B20Ala insulin retains high affinity binding to the receptor, and replacing GlyB20 with alanine most likely modifies the structure of the B-chain in this region, but this structural change appears to enhance binding toThe insulin receptor.

TL;DR: An engineering approach will aid the production of glycoproteins with improved properties and therapeutic potential by constructing a design matrix that facilitates the generation of desired glycosylation, such as human-like α2,6-linked sialic acid capping.

TL;DR: The independent influence of HPV-associated p16-expression in advanced OPC treated with primary RT was confirmed, however, RT-outcome in the group of non-OPC did not differ by tumor p 16-status, indicating that the prognostic impact may be restricted to OPC only.

TL;DR: The detailed pattern-of-failure data analysis suggests that most recurrences occur in the FDG PET positive areas or the solid tumor.