Deposits of clastic carbonate-dominated (calciclastic) sedimentary slope systems in the rock record have been identified mostly as linearly-consistent carbonate apron deposits, even though most ancient clastic carbonate slope deposits fit the submarine fan systems better. Calciclastic submarine fans are consequently rarely described and are poorly understood. Subsequently, very little is known especially in mud-dominated calciclastic submarine fan systems. Presented in this study are a sedimentological core and petrographic characterisation of samples from eleven boreholes from the Lower Carboniferous of Bowland Basin (Northwest England) that reveals a >250 m thick calciturbidite complex deposited in a calciclastic submarine fan setting. Seven facies are recognised from core and thin section characterisation and are grouped into three carbonate turbidite sequences. They include: 1) Calciturbidites, comprising mostly of highto low-density, wavy-laminated bioclast-rich facies; 2) low-density densite mudstones which are characterised by planar laminated and unlaminated muddominated facies; and 3) Calcidebrites which are muddy or hyper-concentrated debrisflow deposits occurring as poorly-sorted, chaotic, mud-supported floatstones. These

Phd by thesis

MYC on the Path to Cancer

Nuclear factor of κB (NF-κB) is a sequence-specific transcription factor that is known to be involved in the inflammatory and innate immune responses. Although the importance of NF-κB in immunity is undisputed, recent evidence indicates that NF-κB and the signalling pathways that are involved in its activation are also important for tumour development. NF-κB should therefore receive as much attention from cancer researchers as it has already from immunologists.

NF-κB in cancer: from innocent bystander to major culprit

ENDF/B-VII.1 Nuclear Data for Science and Technology: Cross Sections, Covariances, Fission Product Yields and Decay Data

Monthly Notices is one of the three largest general primary astronomical research publications. It is an international journal, published by the Royal Astronomical Society. This article 1 describes its publication policy and practice.

Monthly Notices of the Royal Astronomical Society

Das Lymphom im Magen: Eine persistierende interdisziplinäre Herausforderung

It was recently shown that remarkably accurate fission-fragment mass distri- butions can be obtained by treating the nuclear shape evolution as a Brownian walk on previously calculated five-dimensional potential-energy surfaces; the current status of this novel method is described here. As discussed already in the pioneering works by Meitner and Frisch (1) and Bohr and Wheeler (2, 3) in 1939, nuclear fission can be viewed qualitatively as an evolution of the nuclear shape from that of a single compound nucleus to two receding fragments. The character of the shape dynamics is still not well established but, as a step away from a purely statistical approach toward a full dynamical treatment, it is interesting to explore scenarios in which the evolution is strongly dissipative (4, 5). We therefore picture the nuclear fission process as an evolution of the nuclear shape from a rela- tively compact mononucleus to a dinuclear configuration. In the present study, the shape is composed of three smoothly joined quadratic surfaces (6, 7) which are described by a set of parameters,� ={χi}, whose time development is the result of a complicated interplay between a variety of effects.

/pdf/brownian-shape-motion-fission-fragment-mass-distributions-3v99bw3qo9.pdf

Brownian shape motion: Fission fragment mass distributions

In non-small cell lung cancer (NSCLC) the usage of plasma-derived circulating tumor DNA (ctDNA) have come into focus to obtain a comprehensive genetic profile of a given lung cancer. Despite the usage of specific sampling tubes, archived plasma samples as well as inappropriately treated blood samples still cause a loss of information due to cell lysis and contamination with cellular DNA. Our aim was to establish a reliable protocol to rescue ctDNA from such non-informative samples to monitor the mutational landscape in NSCLC. As a proof-of-concept study we used archived plasma samples derived from whole blood EDTA samples of 51 patients suffering from NSCLC. Analysis of the isolated plasma DNA determined only a small fraction of ctDNA in a range of 90-250 bp. By applying a specific purification procedure, we were able to increase the informative ctDNA content and improve in a cohort of 42 patients the detection of driver mutations from 32% to 79% of the mutations found in tissue biopsies. Thus, we present here an easy to perform, time and cost effective procedure to rescue non-informative ctDNA samples, which is sufficient to detect oncogenic mutations in NGS approaches and is therefore a valuable technical improvement for laboratories handling liquid biopsy samples.

Rescue of Non-Informative Circulating Tumor DNA to Monitor the Mutational Landscape in NSCLC

/pdf/nuclear-model-predictions-near-the-neutron-drip-line-2ttzwm0puc.pdf

Peter Möller

Papers

Das Lymphom im Magen: Eine persistierende interdisziplinäre Herausforderung

Brownian shape motion: Fission fragment mass distributions

Rescue of Non-Informative Circulating Tumor DNA to Monitor the Mutational Landscape in NSCLC

Nuclear Model Predictions Near the Neutron Drip Line Relevant to R-Process Nucleosynthesis

Superheavy elements at high angular momenta