Peter Schroeder

TL;DR: It is reported that the UVB response involves tryptophan as a chromophore and it is shown that through the intracellular generation of photoproducts, such as the arylhydrocarbon receptor (AhR) ligand 6-formylindolo[3,2-b]carbazole, signaling events are initiated, which are transferred to the nucleus and the cell membrane via activation of the cytoplasmatic AhR.

TL;DR: The results indicate that the balance of oxidant and antioxidant systems in plasma shifts in favor of accelerated oxidation during ageing, demonstrated by increases of MDA, HNE, GSSG and by the slight decrease of erythrocytic GSH with age.

TL;DR: In response to IR irradiation, mitogen‐activated protein kinase signaling pathways were activated mediating the upregulation of matrix metalloproteinase‐1 expression and shows that IR radiation is capable of specifically interfering with cellular functions and provides a molecular basis for biological effects of IR on human skin.

TL;DR: It is reported that incubation of cultured human dermal fibroblasts or treatment of human skin with specific antioxidants prevented IRA radiation-induced MMP-1 expression in vitro and in vivo, suggesting that IRA irradiation most likely promotes premature skin aging and topical application of appropriate antioxidants represents an effective photoprotective strategy.

TL;DR: IRA-induced expression of matrix metalloproteinase-1 (MMP-1) was found to be mediated by the formation of intracellular reactive oxygen species (ROS) and elicits a retrograde signaling response in human skin.