Peter Wick

TL;DR: While in vitro experiments may never replace in vivo studies, the relatively simple cytotoxic tests provide a readily available pre-screening method for nanomaterials in comparison to existing toxicological data.

TL;DR: The present results indicate that the particles could efficiently enter the cells by a Trojan-horse type mechanism which provoked an up to eight times higher oxidative stress in the case of cobalt or manganese if compared to reference cultures exposed to aqueous solutions of the same metals.

TL;DR: While suspended CNT-bundles were less cytotoxic than asbestos, rope-like agglomerates induced more pronounced cytot toxic effects than asbestos fibres at the same concentrations, which underlines the need for thorough materials characterization prior to toxicological studies and corroborates the role of agglomers in the cytotoxicity effect of nanomaterials.

TL;DR: It will be demonstrated that the many data made available on the biological effects of nanomaterials do not always come from studies that can be considered reliable, thereby contributing to a sustainable improvement of the available data.

TL;DR: The findings suggest that nanomaterials have the potential for transplacental transfer and underscore the need for further nanotoxicologic studies on this important organ system.