Showing papers by "Peyman Salehi published in 2010"

Synthesis of Diheterocyclic Compounds Based on Triazolyl Methoxy Phenylquinazolines via a One-Pot Four-Component-Click Reaction

Abstract: A facile and highly efficient method for one-pot four-component synthesis of triazolyl methoxy phenylquinazolines is described. A mixture of aromatic propargylated aldehydes, different azides, 2-aminobenzophenone derivatives, and ammonium acetate were condensed in the presence of catalytic amounts of acidic ionic liquid, 1-methylimidazolium trifluoroacetate, ([Hmim]TFA), and Cu(OAc)2/sodium ascorbate to afford the corresponding products in excellent yields. This methodology is highly efficient for structurally diverse azides.

A practical and versatile approach toward a one-pot synthesis of 2,3-disubstituted 4(3H)-quinazolinones

Abstract: An effective one-pot three-component route to 4(3H)-quinazolinones from commercially available starting materials is reported. Thus, isatoic anhydride reacted with ammonium acetate or primary amines and aldehydes in the presence of iodine to produce the corresponding quinazolinone derivatives in moderate to good yields.

The composition and antibacterial activity of the essential oil of Levisticum officinale Koch flowers and fruits at different developmental stages

Abstract: The composition and antibacterial activity of the essential oil of Levisticum officinale Koch. at different developmental stages (flower, immature fruit, green mature fruit and ripened fruit) is reported. The essential oils were obtained by hydrodistillation of air-dried samples and their antibacterial activities were tested against seven bacteria. The yield of oil (w/w %) in different stages was in the order: immature fruit (1.5 %) > green mature fruit (1.0 %) > ripened fruit (0.6 %) > flower (0.1 %). The essential oils were analyzed by GC and GC-MS. In total, 27, 31, 28 and 26 constituents were identified and quantified in the mentioned samples, respectively. Monoterpene hydrocarbons were the main group of compounds in the green mature fruit (79.2 %), immature fruit (78.4 %), ripened fruit (75.2 %) and flower (44.0 %). The antibacterial activity of the oils was evaluated by the disk diffusion method using Muller-Hinton agar and determination of inhibition zones. The results of the bioassays showed some variations between the three tested oils in their inhibitory activity against the tested bacteria at a 10 μl disc-1 concentration. The oils from mature and ripened fruit exhibited potent antibacterial activity against Bacillus subtilis, with minimum inhibitory concentration (MIC) values of 0.90 mg ml-1 in mature and ripen fruits.

Biosorption of Ni(II), Cu(II) and Pb(II) by Punica geranatum from Aqueous Solutions

Abstract: In this paper removal of Ni(II), Cu(II) and Pb(II) ions from aqueous solutions by leaves of Punica geranatum were investigated. The biosorption was found to be pH dependent and the highest uptake of all the men- tioned metal ions occurred at pH 4. Furthermore, the influence of other parameters such as initial metal ions concentration and contact time of biosorbent and sorbents were evaluated. Equilibrium data fitted very well to Langmuir model for all studied metals. It was also concluded that the Freundlich isotherm cannot be enough appropriate for the equilibrium data of all three metals. Biosorption of Ni(II), Cu(II) and Pb(II), reached equilibrium in 60, 60 and 30 min, respectively. Moreover, the adsorption rate of the metals can be best described by the second order model.

Essential oil composition and antimicrobial activity of Salvia sahendica Boiss & Buhse. in different phenological stage

Abstract: The objective of this study was the isolation and identificaion of essential oil constituents of Salvia sahendica. The antimicrobial activity of the essential oil was also investigated. The aerial parts of the plant were collected in different phenological stages in 2004 from Sahand Mountain (East Azerbayjan Province, Tabriz). The essential oil of S. sahendica was isolated by hydro-distillation in vegetative, floral budding and full flowering stages. Oils were analyzed by GC and GC/MS methods. The components of the oil were identified by comparison of their mass spectra with those of a computer library or with authentic compounds and confirmed by comparison of their retention indices, either with those of authentic samples or with data published in the literature. Antibacterial activities of the essential oils were tested against seven Gram-positive and Gram-negative bacteria and evaluated by disc diffusion method using Mueller-Hinton agar with determination of inhibition zones. In all samples ?-pinene, ?-pinene, bicyclogermacrene, sabinene and linalool were the major components but with slightly different percentages. The result of bioassay showed that the oil inhibited the growth of all examined bacteria except for Pseudomonas aeruginosa that was resistant to oil samples. The essential oil composition and the observed antibacterial properties show that the oil has a good potential for use in aromatherapy and pharmacy, and support the popular uses of this plant in the folk medicine in Iran.

Enantioselective Addition of Diethylzinc to Aryl Aldehydes Catalyzed by Novel Chiral Imino Alcohol Ligands

Abstract: The enantioselective alkylation of aryl aldehydes by diethylzinc in the presence of catalytic amounts of several novel chiral imino alcohol ligands, synthesized from the reaction of (R)-2-amino-1-butanol with aromatic aldehydes, was studied. The influence of temperature and ligand structure was investigated and enantioselectivity up to 81% was obtained.

Transetherification of Allylic and Benzylic Ethers in the Presence of Ferric Ion.

Abstract: Alcoholysis of allylic, secondary and tertiary benzylic ethers is proceeded efficiently in the presence of catalytic amounts of ferric ion as anhydrous FeCl3 and Fe(ClO4)3.

An Efficient Method for Catalytic Enantioselective Addition of Diethylzinc to Aryl Aldehydes by a C2‐Symmetric Chiral Imino Alcohol.

Abstract: The enantioselective alkylation of aryl aldehydes with diethylzinc in the presence of a C2-symmetric chiral ligand derived from 2-hydroxy-3-pinanone was achieved at room temperature with high enantiomeric excesses.