Showing papers by "Peyman Salehi published in 2023"
TL;DR: In this paper , the authors summarized several decade-long attempts to synthesize new analogues of morphine and codeine and placed a focus on synthetic derivatives derived from ring A (positions 1, 2, and 3), ring C (position 6), and N-17 moiety.
Abstract: Morphine and codeine, two of the most common opioids, are widely used in the clinic for different types of pain. Morphine is one of the most potent agonists for the μ-opioid receptor, leading to the strongest analgesic effect. However, due to their association with serious side effects such as respiratory depression, constriction, euphoria, and addiction, it is necessary for derivatives of morphine and codeine to be developed to overcome such drawbacks. The development of analgesics based on the opiate structure that can be safe, orally active, and non-addictive is one of the important fields in medicinal chemistry. Over the years, morphine and codeine have undergone many structural changes. The biological investigation of semi-synthetic derivatives of both morphine and codeine, especially morphine, shows that studies on these structures are still significant for the development of potent opioid antagonists and agonists. In this review, we summarize several decade-long attempts to synthesize new analogues of morphine and codeine. Our summary placed a focus on synthetic derivatives derived from ring A (positions 1, 2, and 3), ring C (position 6), and N-17 moiety.
TL;DR: In this paper , a series of 12 novel 1,2,3-triazole derivatives were subject to synthesis starting from propargylation of penicillin G followed by copper(I) catalyzed azide alkyne cycloaddition (CuAAC) click reaction.
TL;DR: In this article , N-substituted ?-aminonitrile derivatives from menthol were synthesized by succinic ester formation, propargylation, 1,3-dipolar Huisgen cycloaddition and Strecker reaction.
Abstract: New N-substituted ?-aminonitrile derivatives from menthol were synthesized by
consecutive succinic ester formation, propargylation, 1,3-dipolar Huisgen
cycloaddition and Strecker reaction. The structures of the synthesized
compounds were confirmed by diverse spectroscopic techniques including
1HNMR, 13C-NMR, ESI-MS, and IR. The novel synthesized compounds were
evaluated for their in vitro antibacterial activities against Staphylococcus
aureus as Gram-positive and Escherichia coli as Gram-negative bacteria.
These compounds demonstrated a strong inhibitory effect against S. aureus
with the minimum inhibitory concentration (MIC) values ranged from 32-128 ?g
mL-1. Derivatives 6a2, 6b1, 6b4, and 6b5 with a MIC value of 32 ?g mL-1
exhibited the best inhibitory effects.