Medicinal Chemistry Research 

About: Medicinal Chemistry Research is an academic journal published by Springer Science+Business Media. The journal publishes majorly in the area(s): Docking (molecular) & Chemistry. It has an ISSN identifier of 1054-2523. Over the lifetime, 4215 publications have been published receiving 51787 citations.

Coumarin: a potential nucleus for anti-inflammatory molecules

Abstract: Numerous research reports have indicated the coumarin nucleus as a potential candidate for development of anti-inflammatory drugs. Various phytoconstituents such as umbelliferone, scopoletin, columbiatnetin, visniadin, marmin, and many more derived from coumarin nucleus are found to have potent anti-inflammatory as well as antioxidant activities. A large number of coumarin derivatives have also been designed, synthesized, and evaluated to have mild-to-very potent anti-inflammatory activity through different mechanisms. However, despite the continuing efforts in search of these drugs, no major breakthrough has been achieved so far. In the present review, a critical analysis of various reports on naturally as well as the synthetically derived coumarin derivatives having anti-inflammatory activity has been carried out and a structural–activity relationship around the coumarin nucleus has been proposed to assist the medicinal chemists in rationally designing the anti-inflammatory drugs.

Development of drugs based on imidazole and benzimidazole bioactive heterocycles: recent advances and future directions

Abstract: Imidazole and benzimidazole rings are the most important nitrogen-containing heterocycles, which are widely explored and utilized by the pharmaceutical industry for drug discovery. Due to their special structural features and electron-rich environment, imidazole- and benzimidazole-containing drugs bind to a variety of therapeutic targets, thereby exhibiting a broad spectrum of bioactivities. Numerous imidazole- and benzimidazole-based drugs have been extensively used in the clinic to treat various types of diseases with high therapeutic potential. Due to their enormous medicinal value, the research and development of imidazole- and benzimidazole-containing drugs is an increasingly active and attractive topic of medicinal chemistry. This review enlightens the landscape of the discovery and development of imidazole- and benzimidazole-based drugs with an emphasis on structure activity relationship features (SAR), medicinal chemistry, and their mechanism of action. Furthermore, the present review also provides the recent advances in the development of imidazole- and benzimidazole-based drugs along with new perspectives. We hope that this paper will open up new opportunities for researchers to design future generation novel and potent imidazole- and benzimidazole-containing drugs.

Thiazoles: having diverse biological activities

Abstract: In the last few decades, a lot of work has been done on thiazole ring to find new compounds related to this scaffold to act as antioxidant, analgesic, anti-inflammatory, antimicrobial, antifungal, antiviral, diuretic, anticonvulsant, neuroprotective, and antitumor or cytotoxic drug molecules with lesser side effects. This review presents the up to date development on the design and development of different thiazole derivatives.

Benzimidazole: a medicinally important heterocyclic moiety

Abstract: Benzimidazole nucleus is a constituent of many bioactive heterocyclic compounds that are of wide interest because of their diverse biological and clinical applications. Moreover, benzimidazole derivatives are structural isosters of naturally occurring nucleotides, which allows them to interact easily with the biopolymers of the living system. This created interest in researchers who have synthesized variety of benzimidazole derivatives and screened them for their various biological activities, viz., anticancer, hormone antagonist, antiviral, anti-HIV, anthelmintic, antiprotozoal, antimycobacterial, antihypertensive, anti-inflammatory, analgesic, anxiolytic, antiallergic, coagulant, anticoagulant, antioxidant as well antidiabetic activities.

Indolizine: a biologically active moiety

Abstract: The discovery of camptothecin and its analogs was the major breakthrough through which “Indolizine moiety” came into limelight. Although major part of the research on indolizine derivatives is focused on anticancer drug discovery, these derivatives have also been screened for different biological activities such as antitubercular, antioxidant, antimicrobial, anticancer, and anti-inflammatory activities to name a few. Despite being an important medicinal moiety, a detailed review on the biologically active potential of indolizine derivative is unavailable. To the best of our knowledge, previous reviews on indolizine derivatives mainly focused on their chemistry and synthesis. The present review discusses the versatile nature of indolizine derivatives and their possible mechanism of action. Important SAR points are discussed with each study to highlight the rationale behind the study. Furthermore, the present review also provides information about current/future prospects of the topic and different indolizine derivatives in clinical trials.