Phatchariya Phannasil

TL;DR: The above results suggest that anaplerosis via PC is important for breast cancer cells to support their growth and motility.

TL;DR: The data indicate that the major metabolic roles of PC in invasive breast cancer are primarily anaplerosis, pyruvate cycling and mitochondrial biosynthesis of precursors of cellular components required for breast cancer cell growth and replication.

TL;DR: Recent studies of various miRNAs that control insulin sensitivity, hepatic glucose production and de novo lipogenesis are discussed and how aberrant expression of these mi RNAs contributes to the pathophysiology of diabetes and NAFLD in animal models are discussed.

TL;DR: Bioinformatic analysis of publicly available transcriptomes from the cancer genome atlas (TCGA) dataset revealed an association between expression of c-Myc and PC in primary breast, as well as in lung and colon cancer tissues, suggesting that overexpression of PC is deregulated by c- myc in these cancers.

TL;DR: In this paper, pyruvate carboxylase (PC) expression was found to trigger cell cycle arrest and apoptosis in breast cancer cells, which is consistent with increased cleavage of procaspase 3 and poly polymerase 3.