P
Philimon Gona
Researcher at University of Massachusetts Boston
Publications - 148
Citations - 95915
Philimon Gona is an academic researcher from University of Massachusetts Boston. The author has contributed to research in topics: Framingham Heart Study & Population. The author has an hindex of 70, co-authored 140 publications receiving 73741 citations. Previous affiliations of Philimon Gona include University of Massachusetts System & University of Massachusetts Medical School.
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Journal ArticleDOI
Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand Alters Mitochondrial Membrane Lipids
Ferry Sandra,Mauro Degli Esposti,Kenneth Ndebele,Philimon Gona,David Knight,Magnus Rosenquist,Roya Khosravi-Far +6 more
TL;DR: It is reported that TRAIL signaling induces an alteration in mitochondrial membrane lipids, particularly cardiolipin, which occurs independently of caspase activation and primes mitochondrial membranes to the proapoptotic action of Bid.
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Outcomes reported by the Vascular Quality Initiative and the National Surgical Quality Improvement Program are not comparable.
Francesco A. Aiello,Bing Shue,Nisha Kini,Amy K. Rosen,Louis M. Messina,William P. Robinson,Philimon Gona,Andres Schanzer +7 more
TL;DR: VQI and NSQIP demonstrate substantial concordance for most preoperative variables and poor concords for most postoperative variables, even at identical collection periods, which cannot be used to directly compare risk-adjusted patient outcomes between institutions.
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Burden and changes in HIV/AIDS morbidity and mortality in Southern Africa Development Community Countries, 1990-2017.
Philimon Gona,Clara M. Gona,Suha Ballout,Sowmya R. Rao,Ruth W Kimokoti,Chabila C Mapoma,Ali H. Mokdad +6 more
TL;DR: Great progress in reducing HIV/AIDS burden has been achieved since the peak but more needs to be done, as robust tracking, testing, and early treatment are required, as well as refinement of individual treatment strategies for transient individuals in the region.
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Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induced mitochondrial pathway to apoptosis and caspase activation is potentiated by phospholipid scramblase-3
Kenneth Ndebele,Philimon Gona,Tai-Guang Jin,Nordine Benhaga,Anas Chalah,Mauro Degli-Esposti,Roya Khosravi-Far +6 more
TL;DR: It is reported that exogenous-expression of PLS3 enhances apoptotic death induced by TRAIL by potentiating the mitochondrial arm of the death pathway and it is demonstrated that TRAIL-induced activation of PKC-delta mediates regulation of the P LS3-induced changes in cardiolipin.
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Cardiovascular correlates of platelet count and volume in the Framingham Heart Study
TL;DR: In this analysis, increased platelet count across FHS cohorts was consistently associated with smoking, triglycerides, low-density lipoprotein, and total cholesterol levels, which concordant with the hypothesis that higher platelet counts are associated with less favorable cardiovascular risk profiles.