Philip J. Ebenezer

TL;DR: Results indicate oxidative stress and inflammation in the brain, adrenal glands, and systemic circulation may play a critical role in the development and further exacerbation of PTSD, which may not be solely a neurological pathology but may progress as a systemic condition involving multiple organ systems.

TL;DR: It is demonstrated that the predator exposure/psychosocial stress model of PTSD produces neurotransmitter changes similar to those seen in human patients and may cause a heightened noradrenergic response.

TL;DR: Data show that NOX expression and activity are upregulated specifically in a vulnerable brain region of MCI patients, and suggest that increases in NOX-associated redox pathways in neurons might participate in the early pathogenesis of AD.

TL;DR: Evidence for the interplay between cytokines, angiotensin II and nNOS in the paraventricular nucleus (PVN), for regulating sympathetic outflow in a rat model of CHF is investigated.

TL;DR: In this article, the potential role of age-related metabolic disturbances serving as an important basis for deleterious perturbations in the aging brain was discussed, which not only have important implications for understanding the basis of brain aging, but also may be important to the development of therapeutic interventions which promote successful brain aging.