P
Phillip M. Scott
Researcher at Johns Hopkins University School of Medicine
Publications - 4
Citations - 269
Phillip M. Scott is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Centrosome & Centriole. The author has an hindex of 4, co-authored 4 publications receiving 168 citations.
Papers
More filters
Journal ArticleDOI
A USP28-53BP1-p53-p21 signaling axis arrests growth after centrosome loss or prolonged mitosis.
Bramwell G. Lambrus,Vikas Daggubati,Yumi Uetake,Phillip M. Scott,Kevin M. Clutario,Greenfield Sluder,Andrew J. Holland +6 more
TL;DR: It is shown that centrosome loss or a prolonged mitosis activates a USP28–53BP1–p53–p21 signaling axis that prevents the growth of cells with an increased propensity for mitotic errors.
Journal ArticleDOI
Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer
Zhong Y. Yeow,Zhong Y. Yeow,Bramwell G. Lambrus,Rebecca Marlow,Rebecca Marlow,Kevin H. Zhan,Mary Anne Durin,Mary Anne Durin,Lauren T Evans,Phillip M. Scott,Thao P. Phan,Elizabeth M. Park,Lorena A. Ruiz,Daniela Moralli,Eleanor Knight,Luned M. Badder,Daniela Novo,Syed Haider,Catherine M. Green,Andrew Tutt,Andrew Tutt,Christopher J. Lord,J. Ross Chapman,J. Ross Chapman,Andrew J. Holland +24 more
TL;DR: It is shown that centrosome depletion induces synthetic lethality in cancer cells that contain the 17q23 amplicon, a recurrent copy number aberration that defines about 9% of all primary breast cancer tumours and is associated with high levels of genomic instability.
Journal ArticleDOI
ANKRD26 recruits PIDD1 to centriolar distal appendages to activate the PIDDosome following centrosome amplification
Lauren T Evans,Taylor Anglen,Phillip M. Scott,Kimberly Lukasik,Jadranka Loncarek,Andrew J. Holland +5 more
TL;DR: Using a genome‐wide screen, data support a model in which ANKRD26 initiates a centriole‐derived signal to limit cell proliferation in response to centrosome amplification, and a recurrent AN KRD26 mutation found in human tumors disrupts PIDD1 localization and PIDDosome activation in cells with extra centrosomes.
Journal ArticleDOI
WBP11 is required for splicing the TUBGCP6 pre-mRNA to promote centriole duplication.
Elizabeth M. Park,Phillip M. Scott,Kevin M. Clutario,Katelyn B. Cassidy,Kevin H. Zhan,Scott A. Gerber,Scott A. Gerber,Andrew J. Holland +7 more
TL;DR: A role is identified for a subset of mRNA splicing factors, including WBP11, in centriole biogenesis, required for the splicing of short, weak introns, including those found in TUBGCP6 pre-mRNA.