Early goal-directed therapy in the treatment of severe sepsis and septic shock

GRADE guidelines: 7. Rating the quality of evidence—inconsistency

Background Focused cardiac ultrasound (FoCUS) is a simplified, clinician-performed application of echocardiography that is rapidly expanding in use, especially in emergency and critical care medicine. Performed by appropriately trained clinicians, typically not cardiologists, FoCUS ascertains the essential information needed in critical scenarios for time-sensitive clinical decision making. A need exists for quality evidence-based review and clinical recommendations on its use. Methods The World Interactive Network Focused on Critical UltraSound conducted an international, multispecialty, evidence-based, methodologically rigorous consensus process on FoCUS. Thirty-three experts from 16 countries were involved. A systematic multiple-database, double-track literature search (January 1980 to September 2013) was performed. The Grading of Recommendation, Assessment, Development and Evaluation method was used to determine the quality of available evidence and subsequent development of the recommendations. Evidence-based panel judgment and consensus was collected and analyzed by means of the RAND appropriateness method. Results During four conferences (in New Delhi, Milan, Boston, and Barcelona), 108 statements were elaborated and discussed. Face-to-face debates were held in two rounds using the modified Delphi technique. Disagreement occurred for 10 statements. Weak or conditional recommendations were made for two statements and strong or very strong recommendations for 96. These recommendations delineate the nature, applications, technique, potential benefits, clinical integration, education, and certification principles for FoCUS, both for adults and pediatric patients. Conclusions This document presents the results of the first International Conference on FoCUS. For the first time, evidence-based clinical recommendations comprehensively address this branch of point-of-care ultrasound, providing a framework for FoCUS to standardize its application in different clinical settings around the world.

International Evidence-Based Recommendations for Focused Cardiac Ultrasound

A review of the development and implementation of a 4-year medical student integrated ultrasound curriculum is presented. Multiple teaching and assessment modalities are discussed as well as results from testing and student surveys. Lessons learned while establishing the curriculum are summarized. It is concluded that ultrasound is a well received, valuable teaching tool across all 4 years of medical school, and students learn ultrasound well, and they feel their ultrasound experience enhances their medical education.

/pdf/an-integrated-ultrasound-curriculum-iusc-for-medical-g6vtaudgd0.pdf

An integrated ultrasound curriculum (iUSC) for medical students: 4-year experience.

Background Dalbavancin, a novel lipoglycopeptide with a pharmacokinetic profile that allows weekly dosing, is active against gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). The efficacy of dalbavancin for treatment of skin and skin structure infections (SSSIs) was demonstrated in a phase 2 study. Methods In a phase 3 noninferiority study, patients with complicated SSSIs, including infections known or suspected to involve MRSA, were randomized (ratio, 2 : 1) in a double-blind manner to receive dalbavancin (1000 mg given intravenously on day 1 and 500 mg given intravenously on day 8) or linezolid (600 mg given intravenously or intravenously/orally every 12 h for 14 days). Efficacy was assessed by determining clinical and microbiological responses at the end of therapy and at the test-of-cure visit. Relapses were identified by additional follow-up approximately 1 month later. Results MRSA was identified in 51% of patients from whom a pathogen was isolated at baseline. Dalbavancin and linezolid demonstrated comparable clinical efficacy in the clinically evaluable population at the test-of-cure visit (88.9% and 91.2% success, respectively). The rate of clinical success at the end of therapy was >90% in both arms. Less than 1.0% of patients in either treatment arm experienced relapse after the test-of-cure visit. Both treatments yielded successful microbiological response in excess of 85% among microbiologically evaluable patients at end of therapy and at the test-of-cure visit for all pathogens combined, for all S. aureus strains, and for MRSA. Gastrointestinal symptoms were among the most common adverse events in both arms. A higher proportion of patients in the linezolid arm reported adverse events that were judged by the investigator to be probably/possibly related to treatment (dalbavancin arm, 25.4% of subjects; linezolid arm, 32.2% of subjects). Conclusions Two doses of dalbavancin (1000 mg given on day 1 followed by 500 mg given on day 8) were as well tolerated and as effective as linezolid given twice daily for 14 days for the treatment of patients with complicated SSSI, including those infected with MRSA.

Randomized, Double-Blind Comparison of Once-Weekly Dalbavancin versus Twice-Daily Linezolid Therapy for the Treatment of Complicated Skin and Skin Structure Infections

https://www.medschool.lsuhsc.edu/emergency_medicine/docs/RUSH%20protocol.pdf

The RUSH Exam: Rapid Ultrasound in SHock in the Evaluation of the Critically lll

Assessment of hemodynamic status in a shock state remains a challenging issue in Emergency Medicine and Critical Care. As the use of invasive hemodynamic monitoring declines, bedside-focused ultrasound has become a valuable tool in the evaluation and management of patients in shock. No longer a means to simply evaluate organ anatomy, ultrasound has expanded to become a rapid and noninvasive method for the assessment of patient physiology. Clinicians caring for critical patients should strongly consider integrating ultrasound into their resuscitation pathways.

/pdf/bedside-ultrasound-in-resuscitation-and-the-rapid-ultrasound-20wepano7u.pdf

Bedside Ultrasound in Resuscitation and the Rapid Ultrasound in Shock Protocol

https://www.dtod.ne.jp/ohtablog/images/article10_pdf_003.pdf

The RUSH Exam 2012: Rapid Ultrasound in Shock in the Evaluation of the Critically Ill Patient

ObjectivesTo determine whether peripheral veins can be detected by ultrasound (US) and to determine vein characteristics, as measured by US, that are associated with successful peripheral venous (PV) catheterization in young children.



MethodsThe authors conducted an observational study in the pediatric emergency department (ED), with a convenience sample of children younger than 7 years. They evaluated attempts at PV catheterization in two groups on the basis of the visibility and palpability of the patients' veins: 1) clinically apparent (visible or palpable) and 2) not clinically apparent (nonvisible and nonpalpable). The authors obtained sonographic measurements in a transverse view (vertical diameter, circumference, and area) and in a longitudinal view (maximal uninterrupted length). Practitioners blinded to the US images then attempted to catheterize veins in the usual manner. The proportion of clinically apparent veins and the proportion of veins that were successfully catheterized that were identified by US were assessed, and the association between ultrasonographic vein measurements and success at catheterization, controlling for possible confounders, was determined.



ResultsThe authors assessed 120 attempts (90 clinically apparent and 30 not clinically apparent) at PV catheterization in 83 patients. US detected all 90 clinically apparent veins, and cannulation success rate was 62/90 (69%). In the not clinically apparent vein group, the rate of success was only 3/30 (10%), and US detected all successfully catheterized veins. In no instance was cannulation successful when the vein was not detected by US. Maximal vein length in longitudinal view was an independent predictor of cannulation success in multivariate analysis.



ConclusionsUltrasound appears to be capable of detecting peripheral veins in children younger than 7 years of age, with lack of US vein visualization likely leading to unsuccessful PV placement. Greater vein length visualization may be a useful predictor of successful PV catheterization.

https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1553-2712.2007.tb01812.x

A pilot study of ultrasound analysis before pediatric peripheral vein cannulation attempt.

onography has traditionally been used to assess anatomic abnormalities. However, its value in evaluating physiologic characteristics has recently been recognized, particularly in the care of patients in shock. As the use of point-of-care sonography grows in critical care and emergency medicine, noninvasive assessment of intravascular volume status is increasingly being used to guide therapy of the critically ill. Although intravenous fluid is often the initial treatment in hypotensive patients, aggressive volume resuscitation may be detrimental in some patients and in certain types of shock. Accurate diagnosis of shock state can be challenging because physical findings of hypovolemic, distributive, cardiogenic, and obstructive shock often overlap. Pulmonary artery and central venous pressure catheters, which provide physiologic data such as cardiac output and right atrial pressure, are time-consuming, invasive, and carry considerable risks. Central venous pressure has long been used to guide fluid management; however, data suggest that in critically ill patients, central venous pressure may not correlate with the effective intravascular volume. 1 Furthermore, invasive hemodynamic monitoring has not been shown to benefit patients. 2 Given the importance of determining intravascular volume in shock, a rapid bedside sonographic examination can be instrumental in guiding medical management of critically ill patients. Multiple sonographic protocols now exist for the evaluation of shock, dyspnea, and cardiac arrest. 3,4 This article will describe the use of sonography of the inferior vena cava (IVC) in the evaluation of patients in shock.

https://onlinelibrary.wiley.com/doi/pdf/10.7863/jum.2012.31.12.1885

Phillips Perera

Papers

The RUSH Exam: Rapid Ultrasound in SHock in the Evaluation of the Critically lll

Bedside Ultrasound in Resuscitation and the Rapid Ultrasound in Shock Protocol

The RUSH Exam 2012: Rapid Ultrasound in Shock in the Evaluation of the Critically Ill Patient

A pilot study of ultrasound analysis before pediatric peripheral vein cannulation attempt.

Caval Sonography in Shock A Noninvasive Method for Evaluating Intravascular Volume in Critically Ill Patients