Pierangelo Sardo

TL;DR: Targeting cellular mechanisms not much considered so far suggests the possibility that microtubule-active drugs could modulate brain hyperexcitability, contributing to the hypothesis that cytoskeleton function may affect synaptic processes, relapsing on bioelectric aspects of epileptic activity.

TL;DR: Electrophysiologically identified two types of raphe neurons and showed that LH electrical stimulation at lower frequency induced an excitation of S and F neurons, and suggested a direct and indirect influence of the LH on the serotonergic efferent neuron.

TL;DR: Results demonstrate that TANs constitute a neuronal system that is involved in detecting unpredicted reward events, irrespective of the specific behavioral situation in which such events occur.

TL;DR: Activity of tonically active neurons in the striatum of monkeys trained to make spatially directed movements elicited by visual stimuli presented ipsilaterally or contralaterally to the moving arm is examined to demonstrate that TANs are not limited to motivational processing, but may play a role in the processing of spatial attributes of stimulus and/or movement as well.

TL;DR: It is concluded that tonic striatal neurons are sensitive to temporal aspects of stimulus prediction by demonstrating that neuronal responses to a movement‐triggering signal become more numerous and pronounced when the degree of temporal predictability of that signal was decreased.