P
Pierantonio Menna
Researcher at Università Campus Bio-Medico
Publications - 59
Citations - 4950
Pierantonio Menna is an academic researcher from Università Campus Bio-Medico. The author has contributed to research in topics: Cardiotoxicity & Anthracycline. The author has an hindex of 22, co-authored 51 publications receiving 4522 citations. Previous affiliations of Pierantonio Menna include University of Chieti-Pescara.
Papers
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Journal ArticleDOI
Anthracyclines: Molecular Advances and Pharmacologic Developments in Antitumor Activity and Cardiotoxicity
TL;DR: An overview of issues confirms that anthracyclines remain “evergreen” drugs with broad clinical indications but have still an improvable therapeutic index.
Journal Article
Doxorubicin Irreversibly Inactivates Iron Regulatory Proteins 1 and 2 in Cardiomyocytes Evidence for Distinct Metabolic Pathways and Implications for Iron-mediated Cardiotoxicity of Antitumor Therapy
TL;DR: Monitoring IRP activities in H9c2 rat embryo cardiomyocytes exposed to DOX or to analogues revealed that IRP-2 was inactivated only by ROS, serving guidelines for designing anthracyclines that spare iron homeostasis and induce less severe cardiotoxicity.
Journal ArticleDOI
Cardiotoxicity of antitumor drugs.
TL;DR: Mechanism-based considerations and retrospective analyses of clinical trials now form the basis for a new classification of cardiotoxicity, type I for anthracyclines vs type II for Trastuzumab, which may serve a template to accommodate other paradigms ofCardiotoxicity induced by new drugs and combination therapies.
Book ChapterDOI
Doxorubicin cardiotoxicity and the control of iron metabolism: quinone-dependent and independent mechanisms.
Giorgio Minotti,Stefania Recalcati,Pierantonio Menna,Emanuela Salvatorelli,Gianfranca Corna,Gaetano Cairo +5 more
TL;DR: Experimental evidence suggesting that Doxorubicin (DOX) and other anthracyclines can act at an intracellular level, perhaps by altering the function of iron regulatory proteins (IRP) that serve to maintain low molecular weight iron pool within physiologic concentrations is reviewed.
Journal ArticleDOI
Defective One- or Two-electron Reduction of the Anticancer Anthracycline Epirubicin in Human Heart RELATIVE IMPORTANCE OF VESICULAR SEQUESTRATION AND IMPAIRED EFFICIENCY OF ELECTRON ADDITION
Emanuela Salvatorelli,Simone Guarnieri,Pierantonio Menna,Giovanni Liberi,Antonio M. Calafiore,Maria A. Mariggiò,Alvaro Mordente,Luca Gianni,Giorgio Minotti +8 more
TL;DR: Vesicular sequestration and impaired efficiency of electron addition have separate roles in determining a defective bioactivation of epirubicin to ROS or secondary alcohol metabolites in the human heart.