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Pierluigi De Riu
Researcher at University of Turin
Publications - 5
Citations - 298
Pierluigi De Riu is an academic researcher from University of Turin. The author has contributed to research in topics: Thiocolchicoside & GABAA receptor. The author has an hindex of 4, co-authored 5 publications receiving 218 citations.
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Journal ArticleDOI
Olfactory and gustatory function impairment in COVID-19 patients: Italian objective multicenter-study.
Luigi Angelo Vaira,Claire Hopkins,Giovanni Salzano,Marzia Petrocelli,Andrea Melis,Marco Cucurullo,Mario Ferrari,Laura Gagliardini,Carlotta Pipolo,Giovanna Deiana,Vito Fiore,Andrea De Vito,Nicola Turra,Sara Canu,Angelo Antonio Maglio,Antonello Serra,Francesco Bussu,Giordano Madeddu,Sergio Babudieri,Alessandro G. Fois,Pietro Pirina,Francesco Antonio Salzano,Pierluigi De Riu,Federico Biglioli,Giacomo De Riu +24 more
TL;DR: Objective data on chemosensitive disorders during COVID‐19 are lacking in the Literature and the need for further study is unclear.
Journal ArticleDOI
The muscle relaxant thiocolchicoside is an antagonist of GABAA receptor function in the central nervous system
Mario Carta,Luca Murru,Paolo Botta,Giuseppe Talani,GianPietro Sechi,Pierluigi De Riu,Enrico Sanna,Giovanni Biggio +7 more
TL;DR: The data suggest that TCC is a potent competitive antagonist of GABAAR function, consistent with clinical observations of the epileptogenic effect of this compound, and a proposed agonistic action at two types of inhibitory receptors.
Journal ArticleDOI
Focal and secondarily generalised convulsive status epilepticus induced by thiocolchicoside in the rat.
GianPietro Sechi,Pierluigi De Riu,Ombretta Mameli,Giovanni A. Deiana,Giovanni Antonio Cocco,Giulio Rosati +5 more
TL;DR: It is documents that thiocolchicoside has a powerful convulsant activity in the rat, perhaps due to an antagonistic interaction of the compound with a cortical subtype of the GABA(A) receptor.
Journal ArticleDOI
Brain interstitial fluid and intracellular distribution of phenytoin.
GianPietro Sechi,V. Petruzzi,Giulio Rosati,Salvatore Tanca,Francesco Monaco,Marilena Formato,Laura Rubattu,Pierluigi De Riu +7 more
TL;DR: The data indicate that most of the free unbound PHT which enters the brain parenchyma accumulates in the cellular compartment, and at 60 and 90 min the peak CSF and IF concentrations are delayed; thus, for PHT, an apparent diffusion front from the CSF into the extracellular space of the brain seems to occur.
Journal ArticleDOI
Brain interstitial fluid collected through implanted tissue cages.
GianPietro Sechi,V. Petruzzi,Giulio Rosati,Laura Rubattu,Francesco Tanda,Giovanni A. Deiana,Pierluigi De Riu +6 more
TL;DR: The main physicochem properties of the whole-brain IF were characterized, in comparison with the physicochemical properties of cerebrospinal fluid and blood/serum.