Showing papers by "Pierre Larochelle published in 1992"
TL;DR: The results suggest that gluteal subcutaneous small resistance arteries of male essential hypertensive patients exhibit a decrement in responsiveness to endothelin-1, a potent vasoconstrictor peptide that may contribute to the maintenance of elevated blood pressure.
Abstract: Objective: In experimental models of hypertension in the rat, resistance arteries present a blunted response to endothelin, a potent vasoconstrictor peptide. The primary objective of this study was to investigate whether, as in hypertensive rat blood vessels, the response of human resistance arterie
115 citations
TL;DR: The data suggest that ketoprofen is a safe choice when short-term treatment with a NSAID is indicated in an essential hypertensive patient treated with a converting enzyme inhibitor such as captopril.
Abstract: The effects of non-steroidal anti-inflammatory drugs (NSAIDs) on the blood pressure and renal function of essential hypertensive patients depend on the specific type of NSAID and antihypertensive drug administered. Twelve patients with essential hypertension, aged 35 to 59 years, stabilized (blood pressure less than 140/90 mmHg) with captopril, received ketoprofen (100 mg bid for 7 days) or matching placebo in a randomized double-blind cross-over fashion. A 3-week wash-out period was included between treatment periods. Blood pressure on the first and last days of the placebo treatment period (137 +/- 7 (SD)/80 +/- 8 and 139 +/- 11/81 +/- 9 mmHg) was similar to respective values during ketoprofen therapy (136 +/- 10/79 +/- 7 and 143 +/- 10/81 +/- 9 mmHg). The mean differences in systolic and diastolic blood pressures, at the end of the treatment periods, between ketoprofen and placebo were 4 (95% confidence intervals -5, +13) and 0 (-8, +8) mmHg, respectively. Ketoprofen had no effect on 24-h urinary sodium excretion (160 +/- 33 and 147 +/- 39 mmol/24 h for ketoprofen and placebo, respectively). Ketoprofen was without effect on glomerular filtration rate, renal plasma flow and filtration fraction. In conclusion, our data suggest that ketoprofen is a safe choice when short-term treatment with a NSAID is indicated in an essential hypertensive patient treated with a converting enzyme inhibitor such as captopril.
11 citations
01 Jan 1992
TL;DR: Urinary cGMP/ANF ratio increased significantly after HOWI in the 3 groups and remained higher in pregnant women compared to non pregnant women (p < 0.05).
Abstract: We studied ANF plasma and urinary cGMP concentrations before and after 30 minutes of head-out water immersion (HOWI) in 11 non pregnant normotensive women, 8 normotensive and 8 essential hypertensive pregnant women. ANF (C-terminal, Ser 99- Tyr 126) was measured by radioimmunoassay after extraction. Baseline ANF and plasma cGMP were similar in the 3 groups. Baseline urinary cGMP, cGMP clearance and urinary cGMP/ANF ratio were similar in normotensive pregnant and hypertensive pregnant women but higher in both groups than in non pregnant women (p < 0.05). HOWI induced a similar elevation in ANF plasma and urinary cGMP in the 3 groups (p < 0.05). Urinary cGMP/ANF ratio increased significantly after HOWI in the 3 groups (p < 0.05) and remained higher in pregnant women compared to non pregnant women (p < 0.05).
5 citations