Piet A.J. de Boer

TL;DR: The analysis implicates a role for Tbx3 in repressing a chamber-specific program of gene expression in regions from which the components of the central conduction system are subsequently formed.

TL;DR: Application of this novel nonradioactive in situ hybridization (ISH) protocol permitted the identification and localization of the cells in the developing heart that express low-abundance mRNAs of different members of the Iroquois homeobox gene family that are supposedly involved in cardiac patterning.

TL;DR: These data show how a proliferating growth center in the caudal coelomic wall elongates the heart tube at both its venous and arterial pole, providing a morphological mechanism for early heart formation.

TL;DR: In this paper, the authors made quantitative reconstructions of embryonic chicken hearts ranging in stage from the fusion of the heart-forming fields to early formation of the chambers and found that the early heart tube is recruited from a pool of rapidly proliferating cardiac precursor cells, producing a slowly proliferating straight heart tube composed of cells increasing in size.

TL;DR: Retarded development of the D configuration in the ascending loop of the embryonic heart predisposes the myocardium at the junction of the right ventricle and outflow tract to excessive development of intertrabecular pouches during subsequent development.