P
Pim J. French
Researcher at Erasmus University Rotterdam
Publications - 192
Citations - 15017
Pim J. French is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Glioma & Medicine. The author has an hindex of 48, co-authored 154 publications receiving 11638 citations. Previous affiliations of Pim J. French include National Institute for Medical Research & Erasmus University Medical Center.
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Journal ArticleDOI
OS08.1.A Integrative molecular analysis of matched primary and recurrent IDH-mutant astrocytoma; an update from the GLASS-NL consortium
Wies Vallentgoed,Youri Hoogstrate,Erik van Dijk,Karin van Garderen,A. Niers,Martin J. van den Bent,Kaspar Draaisma,P. van Eijk,Iris de Heer,Mathilde C.M. Kouwenhoven,Johan M. Kros,Wendy W.J. de Leng,Mirrelijn M. van Nee,P. Robe,Marleen Smits,M. Tesileanu,Bruce Westerman,M. A. van de Wiel,Bauke Ylstra,Pieter Wesseling,Pim J. French +20 more
TL;DR: Longitudinal methylation profiling of IDH-mutant astrocytoma reveals a shift towards a higher grade at tumor recurrence coinciding with reduced DNA methylation levels, and increased frequency of CNAs, which is explained by the increased number of high grades at recurrence.
Posted ContentDOI
Data from Prognostic Significance of DNA Methylation Profiles at MRI Enhancing Tumor Recurrence: a Report from the EORTC 26091 TAVAREC Trial
TL;DR: In this paper , the authors evaluated the prognostic significance of genome-wide DNA methylation profiles and copy-number variations on the TAVAREC trial samples and concluded that DNA methylations were prognostic for time to progression.
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Abstract 1228: Spatial transcriptomics: Data processing revisited to address noise interference
Levi van Hijfte,Marjolein Geurts,Wies Vallentgoed,Paul H. C. Eilers,Peter A. E. Sillevis Smitt,Reno Debets,Pim J. French +6 more
TL;DR: The DSP Platform platform suffers from significant noise interference when using standard analysis tools that obscure its results and is revised and provided an alternative normalization that adequately addresses noise interference and enables correct interpretation of gene expression data.
Journal ArticleDOI
Medulloblastoma in adults: evaluation of the Dutch society for neuro-oncology treatment protocol
LC Bleeker,Mathilde C.M. Kouwenhoven,Iris de Heer,Birgit I. Lissenberg-Witte,Annette H Gijsbers,Hendrikus J. Dubbink,Johan M. Kros,J.M.M. Gijtenbeek,Erkan Kurt,Carin D. D. van der Rijt,Annemarie T. Swaak-Kragten,Filip De Vos,Hiske L van der Weide,Pim J. French,M. J. van den Bent,Pieter Wesseling,Jacoline E C Bromberg +16 more
TL;DR: In this paper , the authors evaluated the toxicity and efficacy of the Dutch treatment protocol for adult medulloblastoma patients, which is a rare tumor in adults, based on residual disease, histological subtype and extent of disease.
Journal ArticleDOI
P05.04.A Disconcordance between different molecular methods to assess homozygous deletion of theCDKN2A/B locus in IDH-mutant astrocytomas
Wies Vallentgoed,Erik van Dijk,Martin J. van den Bent,Kaspar Draaisma,P. van Eijk,Karin van Garderen,Iris de Heer,Youri Hoogstrate,Mathilde C.M. Kouwenhoven,Johan M. Kros,Wendy W.J. de Leng,Mirrelijn M. van Nee,A. Niers,P. Robe,Marleen Smits,Bruce Westerman,M. A. van de Wiel,Bauke Ylstra,Pieter Wesseling,Pim J. French +19 more
TL;DR: Two techniques to call homozygous deletion (HD) of CDKN2A/B now results in WHO grade 4, even in the absence of microvascular proliferation or necrosis in IDH-mutant astrocytoma patients, as well as survival analysis and agreement score are compared.