R
Reno Debets
Researcher at Erasmus University Rotterdam
Publications - 162
Citations - 7326
Reno Debets is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: T cell & T-cell receptor. The author has an hindex of 41, co-authored 140 publications receiving 6216 citations. Previous affiliations of Reno Debets include Erasmus University Medical Center & Rotterdam University of Applied Sciences.
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Journal ArticleDOI
Treatment of Metastatic Renal Cell Carcinoma With Autologous T-Lymphocytes Genetically Retargeted Against Carbonic Anhydrase IX: First Clinical Experience
Cor H. J. Lamers,Stefan Sleijfer,Arnold G. Vulto,Wim H. J. Kruit,M. Kliffen,Reno Debets,Jan W. Gratama,G. Stoter,Egbert Oosterwijk +8 more
Journal ArticleDOI
Treatment of Metastatic Renal Cell Carcinoma With CAIX CAR-engineered T cells: Clinical Evaluation and Management of On-target Toxicity
Cor H. J. Lamers,Stefan Sleijfer,Sabine van Steenbergen,Pascal van Elzakker,Brigitte A. van Krimpen,Corrien Groot,Arnold G. Vulto,Michael A. den Bakker,Egbert Oosterwijk,Reno Debets,Jan W. Gratama +10 more
TL;DR: In-patient proof is provided that the observed "on-target" toxicity is antigen-directed and can be prevented by blocking antigenic sites in off-tumor organs and allowing higher T cell doses.
Journal ArticleDOI
Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy
Gavin M. Bendle,Carsten Linnemann,Anna I. Hooijkaas,Laura Bies,Moniek A. de Witte,Annelies Jorritsma,Andrew Kaiser,Nadine Pouw,Reno Debets,Elisa Kieback,Wolfgang Uckert,Ji-Ying Song,John B. A. G. Haanen,Ton N. Schumacher +13 more
TL;DR: It is shown that lethal cytokine-driven autoimmune pathology can occur in mouse models of TCR gene therapy under conditions that closely mimic the clinical setting and it is demonstrated that adjustments in the design of gene therapy vectors and target T cell populations can be used to reduce the risk of T CR gene therapy–induced autoimmune pathology.
Journal ArticleDOI
Immune responses to transgene and retroviral vector in patients treated with ex vivo-engineered T cells
Cor H. J. Lamers,Ralph Alexander Willemsen,Pascal van Elzakker,Sabine van Steenbergen-Langeveld,Marieke Broertjes,J.C. Oosterwijk-Wakka,Egbert Oosterwijk,Stefan Sleijfer,Reno Debets,Jan W. Gratama +9 more
TL;DR: It is documented the novel feature that therapeutic cells, which were ex vivo engineered by means of transduction with a minimal γ-retroviral vector, do express immunogenic vector-encoded epitopes, which might compromise persistence of these cells.
Journal ArticleDOI
Two Novel IL-1 Family Members, IL-1δ and IL-1ε, Function as an Antagonist and Agonist of NF-κB Activation Through the Orphan IL-1 Receptor-Related Protein 2
Reno Debets,Jackie C. Timans,Bernhard Homey,Sandra Zurawski,Theodore R. Sana,Sylvia Lo,Janet Wagner,Gina Edwards,Teresa Clifford,Satish Menon,J. Fernando Bazan,Robert A. Kastelein +11 more
TL;DR: IL-1δ and ε may constitute an independent signaling system, analogous to IL-1αβ/receptor agonist and Il-1R1, that is present in epithelial barriers of the authors' body and takes part in local inflammatory responses.