Ping-Yi Wu

TL;DR: Host proteases that proteolytically activate the SARS-CoV-2 spike protein, critical for its fusion after binding to angiotensin-converting enzyme 2 (ACE2), as antiviral targets are focused on.

TL;DR: Host proteases that proteolytically activate the SARS-CoV-2 spike protein, critical for its fusion activity after binding to ACE2 receptor, as antiviral targets are focused on, revealing that, similar to camostat, CMK blocks virus entry, but it further suppresses the cleavage of spike and syncytium.

TL;DR: A panel of mRNA-LNP-based vaccines using the receptor binding domain (RBD) of Omicron and Delta variants, which are dominant in the current wave of COVID-19 are developed to lay a foundation for rational development of the next generation vaccines against SARS-CoV-2 VOCs.

TL;DR: The data demonstrate that cancer immunotherapy using membrane-bound IL-12 has the advantage of minimizing systemic IL- 12 levels without compromising its antitumor efficacy, and is effective in both local and systemic suppression of unmodified tumors.

TL;DR: It is demonstrated that AAV8-delivered IL-15-IL-15RalphaS provides an effective and safe therapy against metastatic HCC.