P
Pleuni Ooievaar-De Heer
Researcher at University of Amsterdam
Publications - 2
Citations - 129
Pleuni Ooievaar-De Heer is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Antibody & Monoclonal antibody. The author has an hindex of 2, co-authored 2 publications receiving 121 citations.
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Journal ArticleDOI
Human IgG4 Binds to IgG4 and Conformationally Altered IgG1 via Fc-Fc Interactions
Theo Rispens,Pleuni Ooievaar-De Heer,Ellen Vermeulen,Janine Schuurman,Marijn Van Der Neut Kolfschoten,Rob C. Aalberse +5 more
TL;DR: It is proposed that the IgG4-IgG4 Fc interaction resembles an intermediate of the Fab-arm (half-molecule) exchange reaction that is stabilized because one of the Igg4 molecules is coupled to a solid phase.
Journal ArticleDOI
Traces of pFc’ in IVIG interact with human IgG Fc domains and counteract aggregation
TL;DR: In this paper, it was shown that IVIG treated with traces of pepsin (Nanogam) inhibits Fc-Fc interactions, and that pFc' formation explains how limited pepsins digestion diminishes adverse effects of IVIG.