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Pontus Boström
Researcher at Karolinska Institutet
Publications - 41
Citations - 10722
Pontus Boström is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Lipid droplet & Lipid metabolism. The author has an hindex of 26, co-authored 40 publications receiving 9173 citations. Previous affiliations of Pontus Boström include Sahlgrenska University Hospital & University of Gothenburg.
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Journal ArticleDOI
Cytosolic Lipid Droplets Increase in Size by Microtubule-Dependent Complex Formation
Pontus Boström,Mikael Rutberg,Johanna Ericsson,Peter Holmdahl,Linda Andersson,Michael A. Frohman,Jan Borén,Sven-Olof Olofsson +7 more
TL;DR: Lipid droplets can grow after they have been assembled, and the presence of dynein on ADRP-containing droplets supports a role for this motor protein.
Journal ArticleDOI
Hypoxia Converts Human Macrophages Into Triglyceride-Loaded Foam Cells
Pontus Boström,Björn Magnusson,Per-Arne Svensson,Olov Wiklund,Jan Borén,Lena M. S. Carlsson,Marcus Ståhlman,Sven-Olof Olofsson,Lillemor Mattsson Hultén +8 more
TL;DR: The results demonstrate that exposure of human macrophages to hypoxia causes an accumulation of triglyceride-containing cytosolic lipid droplets, indicating that the Hypoxia present in atherosclerotic lesions can contribute to the formation of the lipid-loaded macrophage that characterize the lesion and to the accumulation oflycerides in such lesions.
Journal ArticleDOI
PLD1 and ERK2 regulate cytosolic lipid droplet formation.
Linda Andersson,Pontus Boström,Johanna Ericson,Mikael Rutberg,Björn Magnusson,Denis Marchesan,Michelle Ruiz,Lennart Asp,Peang Huang,Michael A. Frohman,Jan Borén,Sven-Olof Olofsson +11 more
TL;DR: PLD1 has been identified as the relevant isoform, and extracellular signal-regulated kinase 2 (ERK2) as the cytosolic protein, and dynein is a possible target for ERK2 in basal lipid droplet formation.
Journal ArticleDOI
Adipocyte differentiation-related protein promotes fatty acid storage in cytosolic triglycerides and inhibits secretion of very low-density lipoproteins.
Björn Magnusson,Lennart Asp,Pontus Boström,Michel Ruiz,Pia Stillemark-Billton,Daniel Lindén,Jan Borén,Sven-Olof Olofsson +7 more
TL;DR: An increase in the expression of ADRP increased triglyceride accumulation in cytosolic lipid droplets and prevented the incorporation of fatty acids into secretable triglycerides, thereby reducing the secretion of triglycerides as well as of apolipoprotein B-100 (apoB-100) and apoB-48 VLDL.
Journal ArticleDOI
The VLDL receptor promotes lipotoxicity and increases mortality in mice following an acute myocardial infarction
Jeanna Perman,Pontus Boström,Malin Lindbom,Ulf Lidberg,Marcus Ståhlman,Daniel Hägg,Henrik Lindskog,Margareta Scharin Täng,Elmir Omerovic,Lillemor Mattsson Hultén,Anders Jeppsson,Petur Petursson,Johan Herlitz,Gunilla Olivecrona,Dudley K. Strickland,Kim Ekroos,Sven-Olof Olofsson,Jan Borén +17 more
TL;DR: It is suggested that VLDLR-induced lipid accumulation in the ischemic heart worsens survival by increasing ER stress and apoptosis.