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Priscilla De Rosa
Researcher at Casa Sollievo della Sofferenza
Publications - 2
Citations - 254
Priscilla De Rosa is an academic researcher from Casa Sollievo della Sofferenza. The author has contributed to research in topics: PINK1 & Autophagosome. The author has an hindex of 2, co-authored 2 publications receiving 194 citations.
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PINK1 and BECN1 relocalize at mitochondria-associated membranes during mitophagy and promote ER-mitochondria tethering and autophagosome formation
Vania Gelmetti,Priscilla De Rosa,Liliana Torosantucci,Elettra Sara Marini,Alessandra Romagnoli,Martina Di Rienzo,Giuseppe Arena,Domenico Vignone,Gian Maria Fimia,Enza Maria Valente +9 more
TL;DR: It is shown that, following mitophagic stimuli, autophagosomes also form at MAM; moreover, endogenous PINK1 and BECN1 were both found to relocalize at M AM, where they promoted the enhancement of ER-mitochondria contact sites and the formation of omegasomes, that represent autophagy precursors.
Journal ArticleDOI
Candidate genes for Parkinson disease: Lessons from pathogenesis.
TL;DR: Findings implicating the main PD-related proteins in biological processes such as mitochondrial dysfunction, misfolded protein damage, alteration of cellular clearance systems, abnormal calcium handling and altered inflammatory response, which represent key targets for neuroprotection are summarized.