Pu-Sheng Wang

TL;DR: The first enantioselective α-allylation of aldehydes with terminal alkenes has been realized by combining asymmetric counteranion catalysis and palladium-catalyzed allylic C-H activation, thus affording allylation products in high yields and with good to excellent levels of enantiOSElectivity.

TL;DR: A variety of polycyclic compounds bearing multistereogenic centers were obtained in high yields and excellent enantioselectivities from the relay catalytic cascade reaction between (2-(but-3-en-1-ynyl)phenyl) silanols and quinones catalyzed by the combined achiral gold complex and chiral N-triflyl phosphoramide.

TL;DR: A highly enantioselective allylic C-H alkylation reaction of allylarenes with pyrazol-5-ones has been established by the cooperative catalysis of a chiral palladium complex and chiral Brønsted acid to afford a wide spectrum of functionalized chiral N-heterocycles with an all-carbon quaternary stereogenic center in high yields and with high levels of enantiOSElectivity.

TL;DR: An enantioselective intramolecular allylic C-H oxidation to generate optically active chromans has been accomplished under the cooperative catalysis of a palladium complex of chiral phosphoramidite ligand and 2-fluorobenzoic acid.

TL;DR: This Account focuses on describing the origin, evolution, and synthetic applications of Pd-catalyzed asymmetric allylic C-H functionalization reactions, with an emphasis on the fundamental mechanism of the concerted proton and two-electron transfer process in allylicC-H activation.