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Qian Shao
Researcher at Scripps Research Institute
Publications - 21
Citations - 2648
Qian Shao is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Enantioselective synthesis & Oxazoline. The author has an hindex of 15, co-authored 21 publications receiving 1887 citations. Previous affiliations of Qian Shao include Peking University.
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Journal ArticleDOI
Palladium-Catalyzed Transformations of Alkyl C-H Bonds.
TL;DR: A number of mono- and bidentate ligands have also proven to be effective for accelerating C(sp3)-H activation directed by weakly coordinating auxiliaries, which provides great opportunities to control reactivity and selectivity in Pd-catalyzed C-H functionalization reactions.
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From Pd(OAc)2 to Chiral Catalysts: The Discovery and Development of Bifunctional Mono-N-Protected Amino Acid Ligands for Diverse C-H Functionalization Reactions.
TL;DR: Mechanistic studies indicate that MPAAs operate as unique bifunctional ligands for C-H activation in which both the carboxylate and amide are coordinated to Pd, and enable numerous Pd(II)-catalyzed C( sp2)-H and C(sp3)-H functionalization reactions of synthetically relevant substrates under operationally practical conditions with excellent stereoselectivity when applicable.
Journal ArticleDOI
Enantioselective remote meta-C–H arylation and alkylation via a chiral transient mediator
TL;DR: Remote, enantioselective remote C–H activation using a catalytic amount of a chiral norbornene as a transient mediator, which relays initial ortho-C–Hactivation to the meta position, is reported.
Journal ArticleDOI
Pd(II)-Catalyzed Enantioselective C(sp3)–H Borylation
TL;DR: Pd(II)-catalyzed enantioselective borylation of C(sp3)-H bonds has been realized for the first time using chiral acetyl-protected aminomethyl oxazoline ligands.
Journal ArticleDOI
Formation of α-chiral centers by asymmetric β-C(sp3)–H arylation, alkenylation, and alkynylation
Qingfeng Wu,Peng-Xiang Shen,Jian He,Xiao-Bing Wang,Forrest Zhang,Qian Shao,Ru-Yi Zhu,Claudio Mapelli,Jennifer X. Qiao,Michael A. Poss,Jin-Quan Yu +10 more
TL;DR: The design of chiral mono-protected aminomethyl oxazoline ligands that enable desymmetrization of isopropyl groups via palladium insertion into the C(sp3)–H bonds of one of the prochiral methyl groups are reported.