Qian Wang

TL;DR: The GFOLD (generalized fold change) algorithm is presented, which overcomes the shortcomings of P-value and fold change calculated by existing RNA-seq analysis methods and gives more stable and biological meaningful gene rankings when only a single biological replicate is available.

TL;DR: This analysis suggests that the binding of ESR1, RARA, and RARG has both activating and repressive effects, and a curated database of 88 nuclear receptor cistrome data sets and other associated high-throughput data sets constitutes a valuable resource for the nuclear receptor and cancer community.

TL;DR: Genetic deletion of Setdb1 reduced EZH2 binding as well as histone 3 lysine 27 (H3K27) trimethylation level at SETDB1 solo peaks and facilitated neural differentiation, and it was found that H3K 27me3 inhibits SETDB 1 methyltransferase activity.

TL;DR: A novel NR2F2 loss-of-function mutation is associates with an increased susceptibility to double outlet right ventricle in humans, which provides further significant insight into the molecular mechanisms underpinning CHD, suggesting potential implications for genetic counseling of CHD families and personalized treatment of patients.

TL;DR: This study first associates MEF2C loss-of-function mutation with DORV in humans, which provides novel insight into the molecular pathogenesis ofCHD, suggesting potential implications for genetic counseling and personalized treatment of CHD patients.