Qiang Wang

TL;DR: Glutamine strengthens the antioxidant capacity in PC12 cells induced by MPP+ through inhibiting the activation of the PI3K/Akt signaling pathway, suggesting that glutamine offers protection against oxidative stress injury in 1-methyl-4-phenylpyridinium-induced Parkinson’s disease cell model.

TL;DR: In vivo the administration of glutamine was found to ameliorate behavioral deficits and neuron damage, increase superoxide dismutase (SOD) and glutathione peroxidase (GSH-XP) activity, reduce the malondialdehyde content, and activate the Wnt3a/β-catenin signaling pathway in SAMP8 mice.

TL;DR: This study demonstrates that the “olfactory three-needle” enhances spatial learning and memory ability by inhibiting the phosphorylation of p38MAPK and the excessive activation of MG to reduce the neuroinflammatory response and neurotoxicity of Aβ and promote synaptic regeneration, but it was not completely consistent with the stimulation of the olfactory system.

TL;DR: In this paper, the role and potential mechanism of miR-20a-5p on inflammation and oxidative stress in 1-methyl-4-phenyl pyridine ion- (MPP+-) induced HT22 cells were explored.

TL;DR: In this paper, the effects and mechanism of acupuncture on the pathophysiology and gastrointestinal function of Parkinson disease was explored, and a PD mouse model was established by rotenone, and electroacupuncture was used to regulate the gastrointestinal function.