Qing-Fei Zhao

TL;DR: NPS were observed to be highly prevalent in AD patients, and disease duration, age, education level, population origin and the severity of cognitive impairment had influence on the prevalence of some NPS.

TL;DR: Effective interventions in diet, medications, biochemical exposures, psychological condition, pre-existing disease and lifestyle may decrease new incidence of AD.

TL;DR: The strongest positive associations between risk factors and the progression from MCI to AD were found for abnormal cerebrospinal fluid (CSF), phosphorylated τ (p-τ) and abnormal CSF τ level, hippocampal and medial temporal lobe atrophy and entorhinal atrophy.

TL;DR: Both low and high education showed a trend of dose-response relation with risk of dementia and AD, and the dementia risk was reduced by 7 % for per year increase in education.

TL;DR: It has been demonstrated that interference of S-nitrosylation could potentially protect from mitochondrial dysfunction, synaptic loss, or neuronal cell death in AD animal models, and the recent advances and challenges in targeting S-Nitrosylated proteins for AD therapies are presented.