Q
Qinyu Yao
Researcher at Xi'an Jiaotong University
Publications - 12
Citations - 306
Qinyu Yao is an academic researcher from Xi'an Jiaotong University. The author has contributed to research in topics: Phosphorylation & Ubiquitin ligase. The author has an hindex of 6, co-authored 12 publications receiving 160 citations.
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Journal ArticleDOI
Nuciferine ameliorates hepatic steatosis in high-fat diet/streptozocin-induced diabetic mice through a PPARα/PPARγ coactivator-1α pathway.
Chao Zhang,Jianjun Deng,Dan Liu,Xingxia Tuo,Lei Xiao,Baochang Lai,Qinyu Yao,Jia Liu,Haixia Yang,Nanping Wang,Nanping Wang +10 more
TL;DR: The effects of nuciferine on lipid and glucose metabolism in a murine model of Type 2 diabetes mellitus (T2DM) is investigated and the underlying mechanisms of these effects are determined.
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Peroxisome proliferator–activated receptor γ (PPARγ) induces the gene expression of integrin αVβ5 to promote macrophage M2 polarization
TL;DR: Novel evidence is provided that PPARγ-mediated gene expression and the ensuing ligation of integrins αV and β5 are implicated in macrophage M2 polarization.
Journal ArticleDOI
Procyanidin B2 Activates PPARγ to Induce M2 Polarization in Mouse Macrophages.
Ying Tian,Chunmiao Yang,Qinyu Yao,Lei Qian,Jia Liu,Xinya Xie,Wen Ma,Xin Nie,Baochang Lai,Lei Xiao,Nanping Wang +10 more
TL;DR: Findings support the notion that PCB2 regulated macrophage M2 polarization via the activation of PPARγ, and provide a new mechanism by which procyanidins exert their beneficial anti-inflammatory effects.
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Docosahexaenoic acid attenuates adipose tissue angiogenesis and insulin resistance in high fat diet-fed middle-aged mice via a sirt1-dependent mechanism.
TL;DR: Overall, the findings demonstrated that DHA reduced angiogenesis of adipose tissues and attenuated insulin resistance in HFD-induced obese mice via the activation of Sirt1.
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Sonic hedgehog signaling instigates high-fat diet–induced insulin resistance by targeting PPARγ stability
TL;DR: The finding suggests that Shh in subcutaneous fat decreases PPARγ activity and stability via activation of an ERK-dependent noncanonical pathway, resulting in impaired insulin action, and may serve as a potential therapeutic approach to treat obesity-related diabetes.