Q
Qioachu Wang
Researcher at University of Texas Health Science Center at Houston
Publications - 2
Citations - 7
Qioachu Wang is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: STIM1 & ORAI1. The author has co-authored 1 publications.
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Journal ArticleDOI
S-acylation of Orai1 regulates store-operated Ca2+ entry.
Savannah J. West,Goutham Kodakandla,Qioachu Wang,Ritika Tewari,Michael X. Zhu,Darren Boehning,Askar M. Akimzhanov +6 more
TL;DR: In this article, the authors show that Orai1 is rapidly S-acylated at cysteine 143 upon ER Ca2+ store depletion, leading to the formation of activated CRAC channels.
Journal ArticleDOI
S‐acylation of STIM1 regulates store‐operated calcium entry
Goutham Kodakandla,Savannah J. West,Qioachu Wang,Ritika Tewari,Michael X. Zhu,Askar M. Akimzhanov,Darren Boehning +6 more
TL;DR: It is evident that S‐acylation recruits Orai1 to specialized membrane subdomains to form puncta with STIM1, whose extended conformation is stabilized by S‐ACYlation at its 437 residue, which plays a crucial role facilitate store‐operated calcium entry.