Qiuyan Zhao

TL;DR: Mix-backbone oligonucleotides that contain phosphorothioate segments at the 3' and 5' ends and have a modified oligodeoxynucleotide or oligoribonucleotide segment located in the central portion of the oligon nucleotide indicate improved properties compared with phosphorOTHioate oligodespecies with respect to affinity to RNA, RNase H activation, and anti-HIV activity.

TL;DR: The results show that cell proliferation and immunoglobulin production (IgG and IgM) depend on the sequence and the chemical modification of the oligonucleotide, and that oligon nucleotides exert their effects mainly on the B cells.

TL;DR: In this article, the authors proposed methods for enhancing the immune response caused by immunostimulatory oligonucleotide compounds by using oligonotide analogs as immunotherapy agents in immunotherapy applications.

TL;DR: Structural-immunostimulatory activity relationships of phosphorothioate oligodeoxynucleotides containing YpG- and CpR-motifs containing Y and R stand for pyrimidine and purine analogues are examined to understand the critical role of each functional group of the cytosine and guanine moieties in a CpG -motif in inducing immunostimulation activity.

TL;DR: A distinct pattern and kinetics of cytokine production following oligonucleotide administration is shown and it is demonstrated that cytokine induction is not a general property of phosphorothioate oligon nucleotides but is dependent on the sequence and dose of the olig onucleotides.